Adenosine Receptors in Neurology and Psychiatry /

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and ps...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mori, Akihisa, 1970- (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London, UK ; Waltham, MA : Elsevier/Academic Press, 2014.
Edición:First edition.
Colección:International review of neurobiology ; v. 119.
Temas:
Adenosine > Receptors.
Adenosine > Pathophysiology.
Adenosine > Physiological effect.
Nervous system > Pathophysiology.
Brain > Pathophysiology.
Adenosine > Antagonists.
Receptors, Purinergic P1 > physiology
Adenosine > physiology
Ad�enosine > R�ecepteurs.
Ad�enosine > Physiopathologie.
Ad�enosine > Effets physiologiques.
Syst�eme nerveux > Physiopathologie.
Cerveau > Physiopathologie.
Ad�enosine > Antagonistes.
Nervous system > Pathophysiology
Adenosine > Physiological effect
Adenosine > Receptors
Brain > Pathophysiology
Acceso en línea:Texto completo
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Tabla de Contenidos:
  • Front Cover; Adenosine Receptors in Neurology and Psychiatry; Copyright; Contents; Contributors; Preface; Chapter One: Adenosine Receptor Neurobiology: Overview; 1. General Introduction; 2. Source and Regulation of Extracellular Adenosine Level; 3. ARs Subtypes: Classification and Gene Structures; 3.1. A novel protein transcribed from a different frame of the A2AR gene; 4. Expression of ARs in the Brain; 4.1. A1 receptor; 4.2. A2A receptor; 4.3. A2B and A3 receptors; 5. Structure Biology of Adenosine A2A Receptors; 6. Canonical and Noncanonical Signaling Pathways of ARs
  • 8. AR Functions: Insights from Pharmacological and Genetic-KO Approaches8.1. AR modulation of neuronal excitability by presynaptic and postsynaptic mechanisms; 8.2. AR modulation of synaptic plasticity; 8.3. AR control of learning and memory; 8.4. ARs control of sleep-wake cycle; 8.5. A2AR control of motor and psychomotor activities; 8.6. Adenoisne receptor control of anxiety, aggression, and depression; 8.7. AR control of angiogenesis; 8.8. AR control of cerebral blood flow and blood-brain barrier integrity; 9. ARs and Glial Functions; 9.1. Glial control of adenosine homeostasis
  • 9.2. Glial ARs10. Pathophysiological Functions of ARs; 11. ARs as Drug Targets; Acknowledgments; References; Further Reading; Chapter Two: Adenosine Receptor PET Imaging in Human Brain; 1. Introduction; 2. PET Imaging of Adenosine A1 Receptors; 2.1. PET ligands for adenosine A1 receptors; 2.2. Adenosine A1 receptors in normal subjects; 2.3. Adenosine A1 receptors in brain diseases; 3. PET Imaging of Adenosine A2A Receptors; 3.1. Ligands for adenosine A2A receptors; 3.2. Adenosine A2A receptors in normal subjects; 3.3. Adenosine A2A receptors in brain diseases; 4. Conclusions; References
  • Chapter Three: An Overview of Adenosine A2A Receptor Antagonists in Parkinson� s Disease1. Problems in the Treatment of Parkinson� s Disease; 2. Non-dopaminergic Approaches to the Treatment of PD; 3. Adenosine A2A Receptor Antagonists and Motor Function; 3.1. Improvement in motor disability; 3.2. Improved motor function without dyskinesia; 4. Adenosine A2A Receptor Antagonists and Nonmotor Symptoms of PD; 5. A2A Adenosine Receptor Antagonists and Neuroprotection in PD; 6. A2A Receptor Antagonists and Clinical Outcomes in PD; 7. Conclusions; References

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