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Biased signaling in physiology, pharmacology and therapeutics /
Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. Written for both new and established scien...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Academic Press,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Biased Signaling in Physiology, Pharmacology and Therapeutics; Copyright Page; Dedication; Contents; Preface; About the Editor; List of Contributors; 1 An Historical Introduction to Biased Signaling; Introduction; Isolation and Characterization of Receptors; Mechansims of Receptor Function; Basic Principles of Receptor Pharmacology; Conformational Dynamics and Biased Signaling; Physiological and Therapeutic Implications of Biased Signaling; Conclusion; References; 2 The Role of the Cell Background in Biased Signaling; Biased Signaling.
- Receptor Interacting Proteins: Defining the Receptor InteractomeG Protein-Coupled Receptors; GPCR-Associated Protein Complexes and the GPCR Interactome; PDZ Proteins; Receptor Oligomerization; Co-Receptors and Accessory Signaling Proteins; Receptor Trafficking; Receptor Tyrosine Kinases; RTK Signaling Networks; The EGF Receptor Signaling Network; Other RTK Networks; The Microenvironment; Conclusion; References; 3 The Application of Signaling Bias to New Therapeutic Drug Therapy for Seven Transmembrane (G Protein-coupled) Receptors: ... ; Introduction.
- A Biased Allosteric Inhibitor of FGF ReceptorsPlatelet-Derived Growth Factor Receptor Inhibition; Conclusion; References; 6 Conformational Mechanisms of Signaling Bias of Ion Channels; Introduction; Ion Channel Overview; Ligand-gated Ion Channel Superfamily; Voltage-gated Ion Channel Superfamily; Other Ion Channel Families; Other Classification Schemes; Ion Channel Structures; Potassium Channel Structure; Ligand-gated Channel Structure; Conformational Dynamics; Allosteric Modulation of Ion Channels; Allosteric Modulation of Ligand-gated Channels.