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Biased signaling in physiology, pharmacology and therapeutics /
Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. Written for both new and established scien...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Academic Press,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Biased signaling in physiology, pharmacology and therapeutics / |c edited by Brian J. Arey. |
| 264 | 1 | |a San Diego, California : |b Academic Press, |c 2014. | |
| 264 | 4 | |c �2014 | |
| 300 | |a 1 online resource (317 pages) : |b illustrations, tables | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index at the end of each chapters. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ebrary, viewed June 19, 2014). | |
| 520 | |a Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly explains biased signaling as an evolved mechanism for physiological systems to decipher complex signals from a limited number of signaling mechanisms. Each chapter is dedicated to a different class of receptor and discusses the scientific basis for biased signaling in the context of how this data affects pharmacology and can be used to develop drugs and treat disease. | ||
| 505 | 0 | |a Front Cover; Biased Signaling in Physiology, Pharmacology and Therapeutics; Copyright Page; Dedication; Contents; Preface; About the Editor; List of Contributors; 1 An Historical Introduction to Biased Signaling; Introduction; Isolation and Characterization of Receptors; Mechansims of Receptor Function; Basic Principles of Receptor Pharmacology; Conformational Dynamics and Biased Signaling; Physiological and Therapeutic Implications of Biased Signaling; Conclusion; References; 2 The Role of the Cell Background in Biased Signaling; Biased Signaling. | |
| 505 | 8 | |a Receptor Interacting Proteins: Defining the Receptor InteractomeG Protein-Coupled Receptors; GPCR-Associated Protein Complexes and the GPCR Interactome; PDZ Proteins; Receptor Oligomerization; Co-Receptors and Accessory Signaling Proteins; Receptor Trafficking; Receptor Tyrosine Kinases; RTK Signaling Networks; The EGF Receptor Signaling Network; Other RTK Networks; The Microenvironment; Conclusion; References; 3 The Application of Signaling Bias to New Therapeutic Drug Therapy for Seven Transmembrane (G Protein-coupled) Receptors: ... ; Introduction. | |
| 505 | 8 | |a A Biased Allosteric Inhibitor of FGF ReceptorsPlatelet-Derived Growth Factor Receptor Inhibition; Conclusion; References; 6 Conformational Mechanisms of Signaling Bias of Ion Channels; Introduction; Ion Channel Overview; Ligand-gated Ion Channel Superfamily; Voltage-gated Ion Channel Superfamily; Other Ion Channel Families; Other Classification Schemes; Ion Channel Structures; Potassium Channel Structure; Ligand-gated Channel Structure; Conformational Dynamics; Allosteric Modulation of Ion Channels; Allosteric Modulation of Ligand-gated Channels. | |
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Pharmacology, Experimental. | |
| 650 | 0 | |a Drug receptors. | |
| 650 | 2 | |a Pharmacology |0 (DNLM)D010600 | |
| 650 | 2 | |a Receptors, Drug |0 (DNLM)D011955 | |
| 650 | 6 | |a Pharmacologie. |0 (CaQQLa)201-0007219 | |
| 650 | 6 | |a Pharmacologie exp�erimentale. |0 (CaQQLa)201-0089582 | |
| 650 | 6 | |a R�ecepteurs de m�edicaments. |0 (CaQQLa)201-0010864 | |
| 650 | 7 | |a pharmacology. |2 aat |0 (CStmoGRI)aat300137970 | |
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| 650 | 7 | |a Drug receptors |2 fast |0 (OCoLC)fst00898699 | |
| 650 | 7 | |a Pharmacology |2 fast |0 (OCoLC)fst01060259 | |
| 650 | 7 | |a Pharmacology, Experimental |2 fast |0 (OCoLC)fst01060280 | |
| 700 | 1 | |a Arey, Brian J., |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Biased signaling in physiology, pharmacology and therapeutics. |d San Diego, California : Academic Press, �2014 |h xv, 300 pages |z 9780124114609 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780124114609 |z Texto completo |