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Molecular Genetic Medicine / Vol. 2.
Molecular Genetic Medicine, Volume II, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The chapters deal with ancient and common genetic diseases, a new infectious disease that threatens to become a world-wide scourge for all of humanity, and two...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
1992.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Molecular Genetic Medicine; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1. The Impact of Molecular Biology on the Diagnosis and Treatment of Hemoglobin Disorders; I. DISEASES OF HEMOGLOBIN; II. GLOBIN GENE ORGANIZATION; III. CONTROL OF GLOBIN GENE EXPRESSION; IV. THALASSEMIAS; V. HEMOGLOBINOPATHIES; VI. ANALYSIS OF GLOBIN GENE FUNCTION; VII. SWITCHING; VIII. GENE THERAPY; Acknowledgments; References; Chapter 2. The fragile X Syndrome; I. INTRODUCTION; II. HISTORY OF THE FRAGILE X SYNDROME; III. EPIDEMIOLOGY OF FRAGILE X SYNDROME
- IV. FEATURES OF AFFECTED AND TRANSMITTING MALESV. THE ASSOCIATION OF FRAGILE X AND AUTISM; VI. CARRIER FEMALES; VII. CYTOGENETICS OF THE FRAGILE X SYNDROME; VIII. TREATMENT; IX. PRENATAL DIAGNOSIS; X. DNA MOLECULAR MARKERS; XI. THEORIES REGARDING THE NATURE OF THE fra(X) MUTATION; XII. APPROACHES TO DEFINE THE NATURE OF THE MUTATION; XIII. CONCLUSIONS; References; Chapter 3. Hepatitis B Virus Biology and Pathogenesis; I. OVERVIEW OF THE PROBLEM; II. DISCOVERY OF THE VIRUS; III. GENETIC ORGANIZATION OF THE HBV GENOME; IV. VIRAL MORPHOGENESIS; V. HEPATOCELLULAR CARCINOMA
- VI. FUTURE PROSPECTS, OPPORTUNITIES, AND CHALLENGESReferences; Chapter 4. The Molecular Genetics of Down Syndrome; I. INTRODUCTION; II. GENE DOSAGE EFFECTS; III. MOLECULAR DEFINITION OF THE DS REGION OF HSA-21; IV. ANIMAL MODELS OF DOWN SYNDROME; V. SUMMARY; Acknowledgments; References; Chapter 5. Mammalian X Chromosome Inactivation; I. INTRODUCTION; II. INITIATION OF X INACTIVATION; III. SPREADING OF THE X INACTIVATION SIGNAL; IV. MAINTENANCE OF X INACTIVATION; V. PERSPECTIVES; Acknowledgments; References
- Chapter 6. Molecular Analysis of Mutation in the Human Gene for Hypoxanthine PhosphoribosyltransferaseI. INTRODUCTION; II. THE HPRT ENZYME AND CLINICAL FEATURES OF HPRT DEFICIENCY; III. LOCALIZATION, STRUCTURE, AND EXPRESSION OF THE hprt GENE; IV. GERM-LINE MUTATIONS IN HPRT-DEFICIENT PATIENTS; V. SOMATIC hprt MUTATIONS; VI. CONSIDERATIONS ABOUT THE SOMATIC AND GERM-LINE MUTATIONAL SPECTRA IN THE HUMAN hprt GENE; References; Chapter 7. Regulatory Genes of Human Immunodeficiency Viruses; I. INTRODUCTION; II. RETROVIRUS LIFE CYCLE; III. COUPLING OF VIRUS REPLICATION TO CELL CYCLE AND ACTIVATION
- IV. HIV REGULATORY GENESV. THE Tat TRANS-ACTIVATION PATHWAY; VI. EXPANDED REPERTOIRE OF Tat ACTIVITIES; VII. THE Rev TRANS-ACTIVATION PATHWAY; VIII. VIRAL PROTEINS; IX. CONCLUSIONS; References; Index