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NMR metabolomics in cancer research /
The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabol...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, UK ; Phildadelphia, PA :
Woodhead Publishing,
2013.
|
| Colección: | Woodhead Publishing series in biomedicine ;
no. 63. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a �Cuperlovi�c-Culf, Miroslava. | |
| 245 | 1 | 0 | |a NMR metabolomics in cancer research / |c Miroslava �Cuperlovi�c-Culf. |
| 260 | |a Cambridge, UK ; |a Phildadelphia, PA : |b Woodhead Publishing, |c 2013. | ||
| 300 | |a 1 online resource (xxi, 423 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Woodhead publishing series in biomedicine, |x 2050-0289 ; |v number 63 | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 520 | |a The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types. | ||
| 505 | 0 | |a Cover; NMR metabolomics incancer research; Copyright; Contents; List of figures; List of tables; Abbreviations; About the author; 1 Introduction; 1.1 Possibilities of NMR metabolomics in cancer research; 1.2 References; 2 Biology -- cancer metabolic phenotype; 2.1 Cancer metabolic phenotype; 2.2 Drugs aimed at cancer metabolic phenotype; 2.3 References; 3 Experimental methodology; 3.1 Fundamentals of NMR spectroscopy; 3.2 1D NMR in mixture analysis; 3.3 Multidimensional NMR in metabolomics; 3.4 Arrayed NMR experiments; 3.5 Isotope labeling for NMR analysis | |
| 505 | 8 | |a 3.6 Diagnostic magnetic resonance tools based on cancer metabolic phenotype and cancer-induced metabolic changes3.7 References; 4 Metabolomics NMR data preprocessing -- analysis of individual spectrum; 4.1 NMR spectrum preprocessing; 4.2 Qualitative metabolomics; 4.3 STOCSY; 4.4 Quantitative metabolomics; 4.5 Novel metabolite structure analysis; 4.6 References; 5 Metabolomics data analysis -- processing and analysis of a dataset; 5.1 Normalization and scaling; 5.2 Biases and confounders in metabolomics; 5.3 Data analysis; 5.4 Data integration -- polyomics analysis; 5.5 References | |
| 505 | 8 | |a 6 Dynamic metabolic profiling and metabolite network and pathways modeling6.1 Dynamic metabolic data analysis; 6.2 Computational models of metabolic networks; 6.3 References; 7 Biomarker discovery; 7.1 Feature (biomarkers) selection; 7.2 Validation of results in supervised analysis; 7.3 References; 8 NMR metabolomics application by cancer type; 8.1 Breast cancer; 8.2 Brain cancers; 8.3 Lung cancer metabolomics analysis and results; 8.4 Metabolomics analysis of biofluids in cancer research; 8.5 References; 9 Perspectives; Index | |
| 650 | 0 | |a Cancer |x Research. | |
| 650 | 0 | |a Metabolism. | |
| 650 | 0 | |a Nuclear magnetic resonance spectroscopy. | |
| 650 | 1 | 2 | |a Biomedical Research |0 (DNLM)D035843 |
| 650 | 1 | 2 | |a Neoplasms |x metabolism |0 (DNLM)D009369Q000378 |
| 650 | 2 | 2 | |a Magnetic Resonance Spectroscopy |0 (DNLM)D009682 |
| 650 | 2 | 2 | |a Metabolomics |0 (DNLM)D055432 |
| 650 | 2 | |a Metabolism |0 (DNLM)D008660 | |
| 650 | 6 | |a Cancer |x Recherche. |0 (CaQQLa)201-0004697 | |
| 650 | 6 | |a M�etabolisme. |0 (CaQQLa)201-0062122 | |
| 650 | 6 | |a Spectroscopie de la r�esonance magn�etique nucl�eaire. |0 (CaQQLa)201-0072888 | |
| 650 | 6 | |a M�etabolomique. |0 (CaQQLa)000288985 | |
| 650 | 7 | |a metabolism (biological concept) |2 aat |0 (CStmoGRI)aat300254909 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x General. |2 bisacsh | |
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| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
| 650 | 7 | |a Cancer |x Research |2 fast |0 (OCoLC)fst00845497 | |
| 650 | 7 | |a Metabolism |2 fast |0 (OCoLC)fst01017473 | |
| 650 | 7 | |a Nuclear magnetic resonance spectroscopy |2 fast |0 (OCoLC)fst01040333 | |
| 655 | 4 | |a Internet Resources. | |
| 776 | 0 | 8 | |i Print version: |z 9781306182492 |
| 830 | 0 | |a Woodhead Publishing series in biomedicine ; |v no. 63. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9781907568848 |z Texto completo |