Tabla de Contenidos:
  • Front Cover
  • Molecular Action of Toxins and Viruses
  • Copyright Page
  • Table of Contents
  • Editors foreword
  • List of contributors
  • Chapter 1. Diphteria toxin; biological activity, by Tsuyoshi Uchida
  • 1. Introduction
  • 2. Biosynthesis of diphtheria toxin
  • 3. Inhibition of protein synthesis by diphtheria toxin
  • 4. Entry of diphtheria toxin into cells
  • 5. Concluding remarks
  • References
  • Chapter 2. Cholera toxin action and the regulation of hormonesensitive adenylate cyclase, by Gary L. Johnson
  • 1. Introduction
  • 2. Regulation of hormone-sensitive adenylate cyclase3. Action of cholera toxin on adenylate cyclase
  • 4. Future uses of cholera toxin
  • Acknowledgments
  • References
  • Chapter 3. Toxic lectins and related proteins, by Sjur Olsnes and Alexander Pihl
  • 1. Introduction
  • 2. Purification of toxic lectins
  • 3. Structure and physical properties
  • 4. Toxicity
  • 5. Mechanism of action
  • 6. Hybrid toxins
  • 7. Cell agglutination and lymphocyte stimulation
  • 8. Uses in protein and cell fractionation and characterization
  • 9. Anticancer properties
  • 10. Concluding remarksAcknowledgments
  • References
  • Chapter 4. Bacterial cytolysins (membrane-damaging toxins), by J.P. Arbuthnott
  • 1. Introduction
  • 2. Phospholipases
  • 3. Thiol-activated cytolysins
  • 4. Staphylococcal a-toxin
  • 5. Staphylococcal d-toxin
  • 6. Concluding remarks
  • References
  • Chapter 5. The mechanism of action of colicin E2, Colicin E3 and Cloacin DF13, by Karen S. Jakes
  • 1. Introduction
  • 2. Colicin E3 and cloacin DF13
  • 3. Colicin E2
  • 4. Structure-function relationships for colicins E2 and E3 and cloacin DF13: molecular topography5. Possible role of in vivo cleavage of colicin or cloacin in biological activity
  • 6. Model for lethal action of colicins E2 and E3 and cloacin DF13 on sensitive cells
  • Acknowledgments
  • References
  • Chapter 6. Similarities in the action of different toxins, by Simon van Heyningen
  • 1. Proteins with a binding component and an active component
  • 2. ADP-Ribosylation
  • 3. Binding to ganglioside
  • Acknowledgments
  • References
  • Chapter 7. The role of cell membranes in infection with bacterial viruses and colicins, by Manfred Schweiger and Monica Hirsch-Kauffmann1. Introduction
  • 2. The action of colicins on membranes
  • 3. The interactions of bacterial viruses with cell membranes
  • 4. Conclusions
  • Acknowledgments
  • References
  • Chapter 8. Bacteriophage T4 infection mechanisms, by Diet mar Rabussay
  • 1. General introduction
  • 2. T4 and the other T-bacteriophages
  • 3. The T4 genome
  • 4. Growth cycle
  • 5. Infection