Cargando…

Advances in molecular toxicology. Volume seven /

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Fishbein, James C. (Editor ), Heilman, Jacqueline M. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford, UK : Elsevier, 2013.
Edición:First edition.
Temas:
Acceso en línea:Texto completo

MARC

LEADER 00000cam a2200000Ii 4500
001 SCIDIR_ocn857724138
003 OCoLC
005 20231117044918.0
006 m o d
007 cr cnu---unuuu
008 130906s2013 ne ob 001 0 eng d
040 |a N$T  |b eng  |e rda  |e pn  |c N$T  |d OPELS  |d OCLCF  |d OCLCQ  |d YDXCP  |d U3W  |d D6H  |d OTZ  |d SFB  |d TUHNV  |d OCLCO  |d OCL  |d OCLCQ  |d OCLCO 
020 |a 9780444626554  |q (electronic bk.) 
020 |a 0444626557  |q (electronic bk.) 
020 |z 9780444626455 
020 |z 044462645X 
035 |a (OCoLC)857724138 
050 4 |a RA1220.3 
060 4 |a QV 600  |b A244 vol. 7eb 
072 7 |a MED  |x 071000  |2 bisacsh 
082 0 4 |a 615.9  |2 23 
245 0 0 |a Advances in molecular toxicology.  |n Volume seven /  |c edited by James C. Fishbein, Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland, USA ; Jacqueline M. Heilman, Exponent, Inc., Washington, District of Columbia, USA. 
246 3 |a Advances in molecular toxicology.  |n Vol. 7 
250 |a First edition. 
264 1 |a Oxford, UK :  |b Elsevier,  |c 2013. 
300 |a 1 online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
588 0 |a Print version record. 
504 |a Includes bibliographical references and index. 
520 |a Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine. 
505 0 |a Front Cover; Advances in Molecular Toxicology; Copyright; Contents; Contributors; Preface; Chapter One: AHR- and ER-Mediated Toxicology and Chemoprevention; 1. Introduction; 2. AHR Ligands; 2.1. Natural and/or dietary ligands; 2.2. Endogenous ligands; 3. Aryl Hydrocarbon Receptor; 3.1. Mechanism of AHR transactivation; 3.2. The nongenomic pathway; 3.3. Negative feedback regulation of AHR transactivation; 3.4. AHR-regulated signaling and toxicity; 3.5. Adverse human health effects of dioxin-like compounds; 3.6. Adaptive response pathway; 3.7. Developmental pathway 
505 8 |a 6.2. Phenylenediamine arylamine xenobiotics7. Arylamine Drugs and Blood Dyscrasias; 7.1. Procainamide; 7.2. Aminoglutethimide; 7.3. Aminopyrine; 8. Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets; 9. Mixtures Toxicology-Application to Arylamine Free Radicals; 10. Protein Radicals and Toxicity-Future Prospects; 11. Closing Remarks; References; Chapter Three: Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones; 1. Introduction; 2. Exposure to PAHs; 3. Exposure Risks of PAH; 4. DNA Damage by PAH 
505 8 |a 5. PAH Metabolism to DNA-Reactive Metabolites6. Diol-Epoxide Pathway; 7. The Radical Cation Pathway; 8. Depurinating PAH Adducts and AP Sites; 9. Mutagenesis Studies to Address PAH Radical Cations; 10. Evidence for AP Site Formation Due to Radical Cations; 11. Mutagenicity Studies with B[a]P Radical Cation Products; 12. The Quinone Pathway; 13. Exposure to OPAHs; 14. Biological Relevance of OPAH; 15. Conclusion; References; Chapter Four: Nitrogen Oxides Toxicology of the Aerodigestive Tract; 1. Introduction; 2. Chemistry of Reactive Oxygen and Nitrogen Oxide Species and the Scavengers 
650 0 |a Molecular toxicology. 
650 0 |a Toxicology. 
650 2 |a Toxicology  |0 (DNLM)D014116 
650 2 |a Molecular Biology  |0 (DNLM)D008967 
650 6 |a Toxicologie mol�eculaire.  |0 (CaQQLa)201-0197805 
650 6 |a Toxicologie.  |0 (CaQQLa)201-0054329 
650 7 |a toxicology.  |2 aat  |0 (CStmoGRI)aat300251568 
650 7 |a MEDICAL  |x Pharmacology.  |2 bisacsh 
650 7 |a Toxicology  |2 fast  |0 (OCoLC)fst01153364 
650 7 |a Molecular toxicology  |2 fast  |0 (OCoLC)fst01024862 
700 1 |a Fishbein, James C.,  |e editor. 
700 1 |a Heilman, Jacqueline M.,  |e editor. 
776 0 8 |i Print version:  |t Advances in molecular toxicology. Vol. 7  |z 9780444626455  |w (OCoLC)850338693 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/bookseries/18720854/7  |z Texto completo