G protein coupled receptors. Modeling, activation, interactions and virtual screening /

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Conn, P. Michael
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego, Calif. : Academic, 2013.
Colección:Methods in enzymology ; v. 522.
Temas:
Cell receptors > Structure-activity relationships.
G proteins > Receptors.
Receptors, G-Protein-Coupled > analysis
Receptors, G-Protein-Coupled > physiology
Magnetic Resonance Spectroscopy
R�ecepteurs cellulaires > Relations structure-activit�e.
Prot�eines G > R�ecepteurs.
Cell receptors > Structure-activity relationships
G proteins > Receptors
Internet Resources.
Acceso en línea:Texto completo
Texto completo
Tabla de Contenidos:
  • The protein local optimization program and g-protein-coupled receptors:loop restoration and applications to homology modeling
  • Modeling active GPCR conformations
  • Molecular modeling of adenosine receptors
  • Predicting g-protein-coupled receptors families using differet physiochemical properties and pseudo amino acid composition
  • Computational design and experimental characterization of GPCR segment models
  • G-protein-coupled receptor interaction with small GTPases
  • Quantification of receptor tyrosine kinase activiation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SplDA)
  • NMR modeling for detection of small molecule binding to RGS4
  • Group II activators of g-protein signaling: monitoring the interaction of G[alpha] with G-protein motif in the intact cell
  • Homogenous time-resolved fluorescence assay to probe folded G protein-coupled receptors
  • cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors
  • Rhodospin-lipid intereactions studied by NMR
  • Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity
  • Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands
  • From heptahelical bundle to hits from the haystack: structure-based virtual screening for GPCR ligands
  • Kinetics and dynamics in the G protein-coupled receptor signaling cascade
  • Magic angle spinning nuclear magnetic resonance spectroscopy fo G protein-coupled receptors
  • Posttranslation modification of G protein-coupled receptor in relationship to biased agonism
  • Protein S-nitrosylation measurement.

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