Cargando…
The Proteasomal System in Aging and Disease /
This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulat...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam ; Boston, MA :
Elsevier/Amsterdam Press,
2012.
|
| Colección: | Progress in molecular biology and translational science ;
v. 109. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000Ii 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn802058508 | ||
| 003 | OCoLC | ||
| 005 | 20231117044737.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 120711s2012 ne af ob 001 0 eng d | ||
| 040 | |a E7B |b eng |e pn |e rda |c E7B |d OCLCO |d N$T |d YDXCP |d UIU |d OCLCQ |d EBLCP |d OCLCQ |d DEBBG |d OCLCO |d OCLCQ |d DEBSZ |d OCLCO |d OCLCQ |d OCLCO |d OCLCQ |d MEU |d UAB |d OCLCF |d OCLCQ |d OL$ |d UKBTH |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO | ||
| 019 | |a 1112928401 |a 1159610912 | ||
| 020 | |a 9780123978653 |q (electronic bk.) | ||
| 020 | |a 0123978653 |q (electronic bk.) | ||
| 020 | |z 9780123978639 | ||
| 020 | |a 1280851376 | ||
| 020 | |a 9781280851377 | ||
| 020 | |a 9786613711724 | ||
| 020 | |a 6613711721 | ||
| 035 | |a (OCoLC)802058508 |z (OCoLC)1112928401 |z (OCoLC)1159610912 | ||
| 050 | 4 | |a QP551 |b .P76 2012eb | |
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 082 | 0 | 4 | |a 572.6 |2 23 |
| 245 | 0 | 4 | |a The Proteasomal System in Aging and Disease / |c edited by Tilman Grune. |
| 264 | 1 | |a Amsterdam ; |a Boston, MA : |b Elsevier/Amsterdam Press, |c 2012. | |
| 300 | |a 1 online resource (xiii, 422 pages, 10 unnumbered pages of plates) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Progress in molecular biology and translational science, |x 1877-1173 ; |v v. 109 | |
| 546 | |a Text in English. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 8 | |a III. ConclusionReferences; Chapter 3: Immunoproteasomes: Structure, Function, andAntigen Presentation; I. Introduction; II. Immunoproteasome Structure; III. Regulation of Gene Expression; IV. Assembly of the 20S Core; V. Enzymatic Activity; VI. Immunoproteasome Knockout Mice; VII. Immunoproteasome Function; A. Antigen Processing and the Immune Response; B. Nonimmune Roles for I-proteasome; VIII. Mutations and Linkage to Human Disease; References; Chapter 4: Interactions of the Proteasomal System with Chaperones: Protein Triage and ProteinQuality control; I. Introduction | |
| 505 | 8 | |a II. Cytosolic Chaperones: The Hsp FamilyA. High-Molecular-Weight Hsps; 1. Hsp100; 2. Hsp90; 3. Hsp70; 4. Hsp40; B. Small Hsps: Hsp27; C. Regulation of Hsps; III. Refolding or Degradation?; A. BAG-1 and CHIP Inhibition of Chaperones and Promotion of Proteasomal Degradation; B. Hip and Hop: Stabilizing the Refolding Process; C. The Co-chaperone-Independent Decision of Folding or Degradation by sHsps; IV. Heat Shock Response After Proteasome Inhibition; A. Regulation of Classical Hsps After Proteasome Inhibition; B. Regulation of Heme Oxygenase-1 After Proteasome Inhibition | |
| 505 | 8 | |a V. Inhibition of Hsps: Influence on Proteasomal DegradationVI. Hsps and the Proteasomal System During Oxidative Stress and the Aging Process; VII. Neurodegenerative Diseases: Connection to the Hsp Family and the Proteasome; A. Alzheimer Disease; B. Parkinson Disease; VIII. Early-Stage Protein Quality Control and ERAD; A. Yeast: ERAD-L; B. Yeast: ERAD-M/C; C. The Mammalian ERAD Process; D. The ERAD Pathway of Non-glycosylated Proteins; E. Proteasome Inhibition and Its Influence on ER Stress and the Unfolded Protein Response; IX. Conclusion; References; Chapter 5: Proteasome Inhibitors | |
| 520 | |a This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field. | ||
| 650 | 0 | |a Proteomics. | |
| 650 | 0 | |a Aging |x Physiological aspects. | |
| 650 | 0 | |a Diseases |x Physiological aspects. | |
| 650 | 6 | |a Prot�eomique. |0 (CaQQLa)201-0363192 | |
| 650 | 6 | |a Vieillissement |0 (CaQQLa)201-0020292 |x Aspect physiologique. |0 (CaQQLa)201-0374335 | |
| 650 | 6 | |a Maladies |0 (CaQQLa)201-0078919 |x Aspect physiologique. |0 (CaQQLa)201-0374335 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Aging |x Physiological aspects |2 fast |0 (OCoLC)fst00800323 | |
| 650 | 7 | |a Proteomics |2 fast |0 (OCoLC)fst01079785 | |
| 700 | 1 | |a Grune, Tilman, |e editor. | |
| 776 | |z 0-12-397863-7 | ||
| 830 | 0 | |a Progress in molecular biology and translational science ; |v v. 109. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123978639 |z Texto completo |