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Biomarkers of neurological and psychiatric disease /
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely r...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2011.
|
| Colección: | International review of neurobiology ;
v. 101. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 020 | |a 9780123877239 |q (electronic bk.) | ||
| 020 | |a 0123877237 |q (electronic bk.) | ||
| 020 | |a 9780123877185 |q (electronic bk.) | ||
| 020 | |a 0123877180 |q (electronic bk.) | ||
| 035 | |a (OCoLC)770599299 | ||
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| 072 | 7 | |a MED |x 056000 |2 bisacsh | |
| 082 | 0 | 4 | |a 616.8/3 |2 23 |
| 245 | 0 | 0 | |a Biomarkers of neurological and psychiatric disease / |c edited by Paul C. Guest and Sabine Bahn. |
| 260 | |a Amsterdam : |b Elsevier, |c 2011. | ||
| 300 | |a 1 online resource (xx, 450 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a International review of neurobiology, |x 0074-7742 ; |v vol. 101 | |
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist. | ||
| 505 | 0 | |a General overview: biomarkers in neuroscience research -- Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands -- The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders -- Proteomic technologies for biomarker studies in psychiatry: advances and needs -- Converging evidence of blood-based biomarkers for schizophrenia: an update -- Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia -- Immune and neuroimmune alterations in mood disorders and schizophrenia -- Behavioral and molecular biomakers in translational animal models for neuropsychiatric disorders -- Stem cell models for biomarker discovery in brain disease -- The application of multiplexed assay systems for molecular diagnostics -- Algorithm development for diagnostic biomarker assays -- Challenges of introducing new biomarker products for neuropsychiatric disorders into the market -- Toward personalized medicine in the neuropsychiatric field -- Clinical utility of serum biomarkers for major psychiatric disorders -- The future: biomarkers, biosensors, neuroinformatics, and E-neuropsychiatry -- | |
| 505 | 0 | 0 | |t Biomarkers of Neurological and Psychiatric Disease -- |t Contributors -- |g 1. |t : General Overview: Biomarkers in Neuroscience Research -- |t I. The Quest for Biomarkers in Neuroscience -- |t A. Biomarkers in Clinical Practice -- |t B. Biomarkers for the Development of Novel Therapeutics and in Basic Research -- |t II. Tools for Biomarker Discovery in Neuroscience -- |t III. Advancements in Biomarker Discovery in Neuroscience -- |t A. Mouse Models -- |t B. Human Data -- |g 1. |t Postmortem Brain Tissue Studies -- |g 2. |t Cerebrospinal Fluid Studies -- |g 3. |t Plasma Studies -- |t C. Future Directions -- |t IV. Considerations for Biomarker Discovery and Translation in NeuroscienceA. Disease Complexity -- |t B. Sample Quality and Collection -- |t C. Candidate Biomarker Validation -- |t D. Systemic Approaches and Biomarker Initiatives -- |t V. Outlook-The Perspective of Personalized Medicine -- |g 2. |t : Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands -- |t I. Introduction -- |t II. Principles of PET Imaging -- |t III. TSPO for Assessment of Microglial Expression -- |t IV. Challenges Facing PET Imaging of the TSPO -- |t V. Disease Applications -- |t A. Neuroinflammatory DiseasesB. Neurodegenerative Diseases -- |t C. Movement Disorders -- |g 1. |t Parkinson's Disease -- |g 2. |t Huntington's Disease -- |t D. Stroke -- |t E. Neuropsychiatric Diseases -- |t VI. Conclusion -- |g 3. |t : The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders -- |t I. Introduction -- |t II. Microarray Gene Expression Analysis -- |t III. Diagnostic Gene Expression Classifiers -- |t IV. Blood Gene Expression Studies of Neuropsychiatric Disorders -- |t V. MicroRNA Expression Analysis -- |t VI. Pharmacogenomics -- |t VII. Concluding Remarks -- |g 4. |t : Proteomic technologies for biomarker studies in psychiatry: Advances and NeedsI. Introduction -- |t II. The Social Impact of Psychiatric Disorders -- |t III. The Role of Proteomics in Psychiatry -- |t A. What Has Been Done So Far? -- |t IV Proteomic Studies in Psychiatry: What Methods Have Been Used to Date? -- |t A Sample Preparation -- |t B Two-Dimensional Gel Electrophoresis and Mass Spectrometry -- |t C Shotgun Proteomics -- |g 1. |t Label-Free MS -- |g 2. |t Stable Isotope Labeling -- |g 3. |t In Vivo Labeling -- |t D SELDI-TOF -- |t E Metabolomics -- |t F Multiplex Analyte Profiling Approach -- |t G What Is the Best Method for Proteome Characterization? -- |t V Underexplored Proteomic Methods in Psychiatry StudiesA Phosphoproteomics -- |t B SILAC -- |t C MALDI Imaging -- |t VI. The Importance of Validation Experiments in Proteomics for Biomarker Discovery in Psychiatry -- |t A. Validation Technologies -- |g 1. |t Selective Reaction Monitoring -- |g 2. |t ELISA -- |g 3. |t Western Blot -- |g 4. |t Functional Genomics -- |g 5. |t Tissue Microarray -- |g 6. |t Protein Arrays -- |t VII. Clinical Translation -- |t VIII. Summary -- |g 5. |t : Converging evidence of blood-based biomarkers for schizophrenia: An Update -- |t I. Introduction -- |t II. Methodology -- |t A. Compilation of Literature Serum/Plasma Biomarkers -- |t B. Compilation of In-House Serum Biomarkers. |
| 650 | 0 | |a Neurology. | |
| 650 | 0 | |a Psychiatry. | |
| 650 | 0 | |a Neuropsychiatry. | |
| 650 | 2 | |a Neurology |0 (DNLM)D009462 | |
| 650 | 6 | |a Neurologie. |0 (CaQQLa)201-0010247 | |
| 650 | 6 | |a Neuropsychiatrie. |0 (CaQQLa)201-0010249 | |
| 650 | 7 | |a HEALTH & FITNESS |x Diseases |x Alzheimer's & Dementia. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Neurology. |2 bisacsh | |
| 650 | 7 | |a Neurology |2 fast |0 (OCoLC)fst01036390 | |
| 650 | 7 | |a Neuropsychiatry |2 fast |0 (OCoLC)fst01036481 | |
| 650 | 7 | |a Psychiatry |2 fast |0 (OCoLC)fst01081152 | |
| 653 | 0 | 0 | |a centraal zenuwstelsel |
| 653 | 0 | 0 | |a central nervous system |
| 653 | 0 | 0 | |a beschadigingen |
| 653 | 0 | 0 | |a injuries |
| 653 | 0 | 0 | |a neurologie |
| 653 | 0 | 0 | |a neurology |
| 653 | 0 | 0 | |a neurobiologie |
| 653 | 0 | 0 | |a neurobiology |
| 653 | 0 | 0 | |a neurowetenschap |
| 653 | 0 | 0 | |a neuroscience |
| 653 | 0 | 0 | |a biologische ontwikkeling |
| 653 | 0 | 0 | |a biological development |
| 653 | 1 | 0 | |a Human Pathology |
| 653 | 2 | 0 | |a Medicine (General) |
| 653 | 1 | 0 | |a Humane pathologie |
| 653 | 2 | 0 | |a Geneeskunde (algemeen) |
| 700 | 1 | |a Guest, Paul C., |e editor. | |
| 700 | 1 | |a Bahn, Sabine, |e editor. | |
| 830 | 0 | |a International review of neurobiology ; |v v. 101. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123877185 |z Texto completo |