Pharmacology of G protein coupled receptors /

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Neubig, Richard R.
Formato: Electrónico eBook
Idioma:Inglés
Publicado: San Diego, CA : Elsevier, �2011.
Colección:Advances in pharmacology (San Diego, Calif.) ; v. 62.
Temas:
G proteins.
Cell receptors.
Biochemistry.
GTP-Binding Proteins
Receptors, Cell Surface
Biochemistry
Prot�eines G.
R�ecepteurs cellulaires.
Biochimie.
biochemistry.
Acceso en línea:Texto completo

MARC

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245 0 0 |a Pharmacology of G protein coupled receptors /  |c edited by Richard R. Neubig. 
260 |a San Diego, CA :  |b Elsevier,  |c �2011. 
300 |a 1 online resource (xvi, 270 pages) :  |b illustrations. 
336 |a text  |b txt  |2 rdacontent 
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490 1 |a Advances in pharmacology ;  |v v. 62 
504 |a Includes bibliographical references and index. 
520 |a G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. 
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650 0 |a Cell receptors. 
650 0 |a Biochemistry. 
650 2 |a GTP-Binding Proteins  |0 (DNLM)D019204 
650 2 |a Receptors, Cell Surface  |0 (DNLM)D011956 
650 2 |a Biochemistry  |0 (DNLM)D001671 
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650 6 |a R�ecepteurs cellulaires.  |0 (CaQQLa)201-0010863 
650 6 |a Biochimie.  |0 (CaQQLa)201-0001077 
650 7 |a biochemistry.  |2 aat  |0 (CStmoGRI)aat300054538 
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650 7 |a Cell receptors.  |2 fast  |0 (OCoLC)fst00850227 
650 7 |a G proteins.  |2 fast  |0 (OCoLC)fst00936830 
700 1 |a Neubig, Richard R. 
830 0 |a Advances in pharmacology (San Diego, Calif.) ;  |v v. 62. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780123859525  |z Texto completo 

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