Therapeutic applications of quadruplex nucleic acids /

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Neidle, Stephen
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London ; Waltham, MA : Elsevier/Academic Press, 2012.
Edición:1st ed.
Temas:
Therapie
Quadruplex nucleic acids > Therapeutic use.
G-Quadruplexes
Antineoplastic Agents > therapeutic use
Antineoplastic Agents > pharmacology
Neoplasms > drug therapy
Nucleic Acid Conformation
Telomere > chemistry
Acides nucl�eiques > Conformation.
MEDICAL > Pharmacology.
Nucleins�auren
Internet Resources.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • history and milestones
  • Fundamentals of DNA and RNA quadruplex structure and stability
  • Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance
  • Genomic DNA and RNA quadruplexes
  • involvement in gene expression and potential as therapeutic agents
  • Quadruplex targets and human disease
  • applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit
  • Quadruplex ligands
  • chemistry and design
  • selectivity and assays
  • Quadruplex ligands
  • basic biology and assays indirect and direct
  • Quadruplex ligands
  • pharmacology and druggability, ligands in clinical trial and pre-clinical trial development
  • Synthetic quadruplexes and drugs
  • therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding
  • Future directions and conclusions.

Ejemplares similares