Cargando…
Structural genomics /
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from kn...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford :
Academic,
2008-2009.
|
| Colección: | Advances in protein chemistry and structural biology ;
v. 75-77. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
| LEADER | 00000cam a2200000 a 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocn702119193 | ||
| 003 | OCoLC | ||
| 005 | 20231117044549.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 110216s2008 enka ob 001 0 eng d | ||
| 040 | |a N$T |b eng |e pn |c N$T |d OCLCQ |d OPELS |d OCLCQ |d OCLCF |d OCLCO |d EBLCP |d DEBSZ |d OCLCO |d OCLCQ |d OCLCO |d OCLCQ |d LEAUB |d OCLCQ |d OCLCO |d OCLCQ |d OCLCO | ||
| 019 | |a 813225797 | ||
| 020 | |a 9780123814449 |q (electronic bk.) | ||
| 020 | |a 0123814448 |q (electronic bk.) | ||
| 020 | |a 9780123814432 |q (electronic bk.) | ||
| 020 | |a 012381443X |q (electronic bk.) | ||
| 020 | |z 9780123744425 | ||
| 020 | |z 0123744423 | ||
| 020 | |z 9780123744364 | ||
| 020 | |z 0123744369 | ||
| 035 | |a (OCoLC)702119193 |z (OCoLC)813225797 | ||
| 050 | 4 | |a QD431 |b .A3 v.75-77eb | |
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 082 | 0 | 4 | |a 572.8633 |2 22 |
| 245 | 0 | 0 | |a Structural genomics / |c edited by Andrzej Joachimiak. |
| 260 | |a Oxford : |b Academic, |c 2008-2009. | ||
| 300 | |a 1 online resource (3 volumes) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in protein chemistry and structural biology, |x 1876-1623 ; |v v. 75-77 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 505 | 0 | |a Part A. Target selection in structural genomics projects to increase knowledge of protein structure and function space / Phil Carter, David Lee, and Christine Orengo. Development of key technologies for high-throughput cell-free protein production with the extract from wheat embryos / Kazuyuki Takai, Tatsuya Sawasaki, and Yaeta Endo. High-throughput protein purification for X-ray crystallography and NMR / Youngchang Kim [and others] Predicting and characterizing protein functions through matching geometric and evolutionary patterns of binding surfaces / Jie Liang [and others] -- part B. Preparation and characterization of bacterial protein complexes for structural analysis / Allan Matte [and others] Strategies for the cloning and expression of membrane proteins / Christopher M.M. Koth ans Jian Pavander -- part C. High-throughput protein crystallization / Naomi E. Chayen. X-ray diffraction experiment : the last experiment in the structure elucidation process / Maksymilian Chruszcz [and others] The tuberculosis structural genomics consortium : a structural genomics approach to drug discovery / Tracey L. Musa, Thomas R Joerger, and James C. Sacchettini. | |
| 588 | 0 | |a Print version record. | |
| 520 | |a Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. | ||
| 650 | 0 | |a Proteins |x Structure. | |
| 650 | 0 | |a Genomics. | |
| 650 | 6 | |a Prot�eines |x Structure. |0 (CaQQLa)000300025 | |
| 650 | 6 | |a G�enomique. |0 (CaQQLa)201-0363181 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Genomics |2 fast |0 (OCoLC)fst00940228 | |
| 650 | 7 | |a Proteins |x Structure |2 fast |0 (OCoLC)fst01079759 | |
| 700 | 1 | |a Joachimiak, Andrzej. | |
| 776 | 0 | 8 | |i Print version: |t Structural genomics. |d Oxford : Academic, 2008-2009 |z 9780123814432 |w (OCoLC)639868443 |
| 830 | 0 | |a Advances in protein chemistry and structural biology ; |v v. 75-77. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123814432 |z Texto completo |