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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors /
"Since its discovery in 1958, the Catechol-O-methyltransferase (COMT) enzyme has generated a lot of excitement, particularly so in more recent years with the discovery of clinically relevant COMT inhibitors in the late 1980's. While the volume of published research on the COMT enzyme and i...
| Cote: | Libro Electrónico |
|---|---|
| Autres auteurs: | |
| Format: | Électronique eBook |
| Langue: | Inglés |
| Publié: |
Amsterdam ; Boston :
Elsevier/Academic Press,
2010.
|
| Collection: | International review of neurobiology ;
v. 95. |
| Sujets: | |
| Accès en ligne: | Texto completo Texto completo |
Table des matières:
- Preface / Erkki Nissinen
- Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson s disease with dual enzyme inhibition / Erkki Nissinen
- The catechol-O-methyltransferase gene, its regulation and polymorphisms / Elizabeth M. Tunbridge
- Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture? / Timo T. M�y�hnen, Pekka T. �Mnnis�t
- Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms / Thomas M|ller
- Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors / Erkki Nissinen and Pekka T. �Mnnis�t
- The Chemistry of Catechol-O-methyltransferase Inhibitors / David A. Learmonth, �Lsz�l E. Kiss and Pat�rcio Soares-da-Silva
- Toxicology and safety of COMT inhibitors / Kristiina Haasio
- Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment / Concepc�i Marin, J.A. Obeso
- Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson s disease / Seppo Kaakkola
- Catechol-O-methyltransferase and pain / Oleg Kambur & Pekka T. �Mnnis�t.