Clusterin Part B /

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. In this Part B volume, outstanding and original reviews provide an overview and synthesis of the latest thoughts and findings relating to Clusterin. Chapters include CLU Gene express...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bettuzzi, Saverio, Pucci, Sabina
Formato: Electrónico eBook
Idioma:Inglés
Publicado: London : Academic, 2010.
Colección:Advances in cancer research, v. 105
Temas:
Cancer > Research.
Clusterin.
Cancer > Recherche.
Acceso en línea:Texto completo

MARC

LEADER 00000cam a2200000Mi 4500
001 SCIDIR_ocn646869252
003 OCoLC
005 20231117033304.0
006 m o d
007 cr cn|||||||||
008 091008s2010 enka ob 001 0 eng d
040 |a E7B  |b eng  |e rda  |e pn  |c E7B  |d OCLCQ  |d OPELS  |d OCLCQ  |d OCLCF  |d OCLCQ  |d UAB  |d D6H  |d OCLCQ  |d LEAUB  |d UKBTH  |d GZM  |d OCLCO  |d OCLCQ 
020 |a 9780123814296  |q (electronic bk.) 
020 |a 0123814294  |q (electronic bk.) 
035 |a (OCoLC)646869252 
050 4 |a QP552.C56  |b C587 2010eb 
082 0 4 |a 616.9940072  |2 22 
245 0 0 |a Clusterin  |n Part B /  |c edited by Saverio Bettuzzi, Sabina Pucci. 
264 1 |a London :  |b Academic,  |c 2010. 
300 |a 1 online resource (x, 167 pages) :  |b color illustrations. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 0 |a Advances in cancer research,  |x 0065-230X ;  |v v. 105 
504 |a Includes bibliographical references and index. 
588 0 |a Print version record. 
520 |a Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. In this Part B volume, outstanding and original reviews provide an overview and synthesis of the latest thoughts and findings relating to Clusterin. Chapters include CLU Gene expression, CLU and prostate cancer, CLU and breast cancer and CLU and prostate cancer. 
505 0 |a Front Cover; Advances in Cancer Research; Copyright; Contents; Contributors; Chapter 1: Clusterin (CLU) and Prostate Cancer; I. Introduction; II. Briefly About Clinically Relevant Human PCa; III. CLU Signaling in Normal and Transformed Cell Lines; IV. CLU Expression in Human PCa; V. Castration Resistant and Metastatic PCa: The Challenge of CLU Antisense Therapy; VI. Chemoprevention of PCa: A Role for CLU in the Mechanism of Action of GTCs; VII. CLU as Tumor Modulator: Is CLU a Novel Tumor Suppressor Gene?; VIII. Conclusions; Acknowledgments; References 
505 8 |a Chapter 2: The Role of Clusterin (CLU) in Malignant Transformation and Drug Resistance in Breast CarcinomasI. Introduction; II. Localization of CLU in Breast Carcinomas; III. Relationship Between Cytoplasmic CLU and Apoptosis in Breast Carcinomas; IV. Role of CLU in Tumorigenesis and Progression of Breast Carcinomas; V. Prognostic Significance of CLU Expression in Breast Carcinomas; VI. CLU and Resistance to Treatment in Breast Carcinomas; VII. Conclusions; Acknowledgments; References; Chapter 3: CLU and Colon Cancer. The Dual Face of CLU: From Normal to Malignant Phenotype 
505 8 |a I. Introduction: Genes and Proteins in Colorectal CancerII. Genetic Instability and Control of DNA Damage: DNA Double-Strand Breaks Repair; III. Clonal Expansion: Apoptosis Inhibition; IV. CLU in Colorectal Cancer Progression: sCLU and Apoptosis Escape; V. CLU as a New Biomarker for Colon Cancer Screening; VI. Conclusions and Future Perspectives; References; Chapter 4: Clusterin (CLU) and Lung Cancer; I. Introduction; II. Carcinogenesis; III. Progression/Metastasis; IV. Treatment; V. CLU Expression and Prognosis in Patients with Lung Cancer; VI. Conclusions; Acknowledgments; References 
505 8 |a Chapter 5: Clusterin and ChemoresistanceI. Introduction; II. Association of sCLU with Chemoresistance; III. Association of sCLU with Multidrug Resistance; IV. Association of sCLU with Resistance to Irradiation and Oxidative Stress; V. Association of sCLU with Progressive Tumors; VI. Association of sCLU with Resistance to Targeted Therapy (TNF, FAS, TRAIL, HDAC Inhibitors, Herceptin); VII. Induction by Genotoxic and Oxidative Stresses; VIII. Mechanism of Induction of and Cytoprotection by CLU; IX. Strategies to Blockade CLU for Chemosensitization in Cancer Cells; References 
505 8 |a Chapter 6: CLU ""In and Out"": Lookingfor a LinkI. Introduction; II. Normal and Cancer Microecosystem; III. Microenvironment Effects on CLU Expression (the ""IN"" Effect); IV. sCLU Effects on Microenvironment (the ""OUT"" Effect): Up- and Downstream Signals; V. Conclusions and Future Perspectives; References; Chapter 7: Regulation of CLU Gene Expression by Oncogenes and Epigenetic Factors: Implications for Tumorigenesis; I. Introduction; II. Regulation of CLU Expression by Transforming Oncogenes: Early Evidence; III. Regulation of CLU Expression by Protooncogenic Transcription Factors 
650 0 |a Cancer  |x Research. 
650 0 |a Clusterin. 
650 6 |a Cancer  |x Recherche.  |0 (CaQQLa)201-0004697 
650 7 |a Cancer  |x Research.  |2 fast  |0 (OCoLC)fst00845497 
650 7 |a Clusterin.  |2 fast  |0 (OCoLC)fst00864992 
700 1 |a Bettuzzi, Saverio. 
700 1 |a Pucci, Sabina. 
856 4 0 |u https://sciencedirect.uam.elogim.com/science/book/9780123814296  |z Texto completo 

Ejemplares similares