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Advances in protein chemistry. Volume 52, Cytokines /
Our most complete understanding of hormone receptor signaling may be exemplified in a family of hormones and receptors known as the cytokine superfamily. This volume is devoted to describing members of this hormone/receptor family from their molecular structures to their physiological effects. These...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego ; London :
Academic Press,
�1999.
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| Colección: | Advances in protein chemistry ;
v. 52. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Protein Chemistry, Volume 52; Copyright Page; Contents; Preface; Chapter 1. General Classes and Functions of Four-Helix Bundle Cytokines; I. Overview; II. Long-Chain Cytokines Using Homodimeric Type I Cytokine Receptors for Signaling; III. Short-Chain Cytokines Using Homodimeric Tyrosine Kinase Receptors for Signaling: Macrophage Colony-Stimulating Factor, Stem Cell Factor, and FLK2/FLT3 Ligand
- IV. Long-Chain Cytokines Using Leukemia Inhibitory Factor Receptors and/or gp130 for Signaling: Pleiotropic Cytokines: Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, Ciliary Neurotrophic Factor, and Cardiotrophin-1V. Short-Chain Cytokines Using �c for Signaling: Hemopoietic Cytokines: Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Interleukin-5; VI. Cytokines Using Class II Cytokine Receptors for Signaling: Viral Resistance Cytokines: Interferons, Interleukin-10, and Interleukin-12
- VII. Short-Chain Cytokines Using ?c or Interleukin-4 Receptor for Signaling: Acquired Immunity Cytokines: Interleukins-2, -4, -7, -9, -13, and -15VIII. Concluding Comments; References; Chapter 2. Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation; I. Introduction; II. Class 1 of the Superfamily; III. Class 2 of the Superfamily; IV. Comparison of Class 1 and Class 2 Receptors; References; Chapter 3. General Mechanisms of Cytokine Receptor Signaling; I. Introduction
- II. Multicomponent Receptors for the Interleukin 6/Ciliary Neurotrophic Factor Cytokine Family: Shared Signal Transducing Receptor ComponentsIII. Cytokine Binding Drives Receptor Complex Assembly; IV. Homo- or Heterodimerization of Signal Transducing Components is Required for Signaling: JAK Kinases are Preassociated with Signal Transducers; V. Shared Principles of Receptor Activation by Different Cytokine Families and Receptor Tyrosine Kinases; VI. STATs and Other Substrates Activated by Cytokine Receptors
- VII. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine ReceptorsVIII. Phosphatases and Other Regulators of Cytokine Receptor Signaling; IX. Therapeutic Approaches for Modulating Cytokine Signaling; References; Chapter 4. Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function; I. Introduction; II. Structure and Regulation of Hematopoietic Compartment; III. Historical Perspective; IV. Experimental Models to Study Cytokine Receptors; V. Inductive versus Stochastic Models of Hematopoiesis; VI. Cytokine Receptor Signaling