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Tissue remodeling and epithelial morphogenesis /
For more than thirty years, Current Topics in Developmental Biology has provided a forum for dissemination and discussion of new ideas and thought in developmental biology. Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelial, this the...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
London :
Academic Press,
2009.
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| Colección: | Current topics in developmental biology ;
89 |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 020 | |a 9780123749024 |q (electronic bk.) | ||
| 020 | |a 0123749026 |q (electronic bk.) | ||
| 035 | |a (OCoLC)639156294 | ||
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| 082 | 0 | 4 | |a 611.018 |
| 245 | 0 | 0 | |a Tissue remodeling and epithelial morphogenesis / |c edited by Thomas Lecuit. |
| 260 | |a London : |b Academic Press, |c 2009. | ||
| 300 | |a 1 online resource (240 pages) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 0 | |a Current topics in developmental biology ; |v 89 | |
| 588 | 0 | |a Print version record. | |
| 520 | |a For more than thirty years, Current Topics in Developmental Biology has provided a forum for dissemination and discussion of new ideas and thought in developmental biology. Bringing together a series of articles on the structural, functional, and developmental characteristics of epithelial, this thematic volume represents a timely and valuable contribution to an exciting and multi-disciplinary field of study. Because defects in epithelial function and growth control play a major role in human disease-cancerous tumors, spina bifida, cardiac malformations, for example-this volume will be a particular interest to researchers working in cancer drug design and development and those working in therapeutic areas to treat developmental abnormalities. Coverage of current research findings and thought on cell-cell and cell-extracellular matrix interactions gives researchers a better understanding of the processes of remodeling and morphogenesis, which are critical to the development of drugs aimed at disrupting the early formation and proliferation of cancerous tumors. Inclusion of chapters that discuss the most contemporary thought on cell polarity and tissue morphogenesis, providing researchers with a better understanding of the control of cellular organization and polarity (particularly important to researchers who are developing treatments for developmental abnormalities and those working in cancer drug development). Use of a variety of animal models, allowing researchers to compare and contrast the molecular mechanisms that underlie cell-cell and cell-extracelluar matrix interactions in a variety of research models. | ||
| 505 | 0 | |a Front Cover; Current Topics in Developmental Biology; Copyright Page; Contents; Contributors; Preface; Chapter 1: Intercellular Adhesion in Morphogenesis: Molecular and Biophysical Considerations; 1. Introduction; 2. Molecular Basis of Intercellular Adhesion; 2.1. Formation of trans-binding interactionsby classical cadherins; 2.2. Intracellular signaling by cadherins; 2.3. Cytoskeletal responses; 2.4. Cell interfacial tension response and the rise of adhesion energy; 3. Modulation of Intercellular Adhesion in Development; 3.1. Modulation of cadherin-catenin membrane levels | |
| 505 | 8 | |a 3.2. Modulation of cortical cytoskeleton organization and response3.3. Differential expression of cadherin subtypes; 4. Intercellular Adhesion Energy and Morphogenesis; 4.1. Intercellular adhesion energy and tissue surface tension; 4.2. Cell sorting and tissue envelopment; 4.3. Origins of heterotypic adhesion energy; 4.4. Cadherin expression levels versus cytoskeleton remodeling; 4.5. Intercellular adhesion energy and polarity; 4.6. Cell interfacial tension refinements; 4.7. Loss of tissue liquid-like behavior; 4.8. Dynamics; 5. Conclusions; Acknowledgments; References | |
| 505 | 8 | |a Chapter 2: Remodeling of the Adherens Junctions During Morphogenesis1. Introduction; 2. Basic Machinery of the Adherens Junction; 3. Remodeling by Small GTPase; 4. Remodeling by Cadherin Turnover and Endocytosis; 4.1. Basic processes of cadherin recycling; 4.2. p120-catenin-dependent cadherin stabilization; 4.3. MicroRNA-dependent turnover; 4.4. Other mechanisms; 5. Remodeling by Nonclassic Cadherins and Nectins; 5.1. Protocadherins; 5.2. Fat cadherins; 5.3. Nectins; 6. Junctional Remodeling During Morphogenesis; 6.1. Remodeling through actin modulation | |
| 505 | 8 | |a 6.2. Cadherin endocytosis during epithelial cell packing6.3. Classic cadherin regulation during gastrulation and neurulation; 7. Perspectives; Acknowledgments; References; Chapter 3: How the Cytoskeleton Helps Build the Embryonic Body Plan: Models of Morphogenesis from Drosophila; 1. Introduction; 2. Establishing Epithelial Structure; 2.1. Forming the first epithelial cells of the Drosophila embryo; 2.2. Connecting cells by assembling adherens junctions; 3. Epithelial Morphogenesis; 3.1. Internalizing mesoderm: Actomyosincontractility drives apical constriction | |
| 505 | 8 | |a 3.2. Germband extension: Actomyosin contractility driving cell intercalation3.3. Microtubule arrays contributing to gastrulation; 3.4. Dorsal closure: Integrating signaling, the cytoskeleton, and adhesion to drive epithelialsheet migration and sealing; 3.5. Adding complexity to the JNK and Dpp pathways; 3.6. An embarrassment of riches: Five nonreceptor tyrosine kinases regulate dorsal closure; 3.7. Roles for novel regulators of adhesionand the cytoskeleton; 3.8. Powering closure by old and new mechanisms; 3.9. Reaching out to close the gap-Key roles for cellprotrusions in dorsal closure | |
| 650 | 0 | |a Tissue remodeling. | |
| 650 | 0 | |a Morphogenesis. | |
| 650 | 6 | |a Tissus (Histologie) |x Remodelage. |0 (CaQQLa)201-0392298 | |
| 650 | 7 | |a Morphogenesis |2 fast |0 (OCoLC)fst01026447 | |
| 650 | 7 | |a Tissue remodeling |2 fast |0 (OCoLC)fst01151491 | |
| 700 | 1 | |a Lecuit, Thomas. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123749024 |z Texto completo |