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Nitrosoureas : current status and new developments /
Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York :
Academic Press,
1981.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover; Nitrosoureas: Current Status and New Developments; Copyright Page; Table of Contents; Contributors; Preface; Section I: PRECLINICAL STUDIES; Chapter 1. The Development of the Nitrosoureas: A Study in Congener Synthesis; I. N-Nitroso Function; II. Chloroethyl Moiety; III. Antitumor Activity in Animal Tumors; IV. Conclusion; References; Chapter 2. Combination Chemotherapy with Nitrosoureas plus Other Anticancer Drugs against Animal Tumors; I. Introduction; II. Biologic Activity of Nitrosoureas in Combination with Other Anticancer Drugs; III. Discussion; IV. Summary; References.
- Chapter 3. EORTC Studies with Novel NitrosoureasI. Introduction; II. The Chemotherapeutic Activity of HECNU and Other NU Derivatives; III. Selecting among NU Analogs; IV. Conclusion; ACKNOWLEDGMENT; References; Chapter 4. Chemical Decomposition of Chloroethylnitrosoureas; I. Introduction; II. Decomposition of Nitrosoureas; III. Decomposition of Other ""Nitroso"" Compounds; IV. Conclusion; References; Chapter 5. Metabolism of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; V. Conclusions; VI. References.
- Chapter 6. DNA Crosslinking and the Origin of Sensitivity to ChloroethylnitrosoureasI. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 7. Modification of DNA and RNA Bases; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 8. Carbamoylating Activity of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; ACKNOWLEDGMENT; References; Chapter 9. Chromatin and Associated Nuclear Components as Potential Drug Targets; I. Introduction; II. Results.
- III. Conclusion and PerspectivesReferences; Chapter 10. ADP-Ribosylation and DNA Repair as Induced by Nitrosoureas; I. Introduction; II. Results and Discussion; III. Conclusion; ACKNOWLEDGMENT; References; SECTION II: CLINICAL STUDIES; Chapter 11. Subacute and Chronic Toxicities Associated with Nitrosourea Therapy; I. Introduction; II. Pulmonary Toxicity; III. Renal Toxicity; IV. Other Adverse Effects; V. Conclusions; ACKNOWLEDGMENT; References; Chapter 12. The Toxicity of High-Dose BCNU with Autologous Marrow Support; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion.
- v. ConclusionReferences; Chapter 13. Clinical Pharmacology of the Nitrosoureas; I. Introduction; II. General Methods; III. Pharmacokinetic Data; IV. Discussion; V. Conclusion; References; Chapter 14. Nitrosoureas in the Therapy of Hodgkin's Disease; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 15. Hodgkin's Disease and Malignant Lymphomas; I. Introduction; II. Materials and Methods; III. Results and Discussion; IV. Conclusion; References; Chapter 16. CCNU in Combination Chemotherapy Programs for Small-Cell Lung Cancer.