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Mechanisms of drug resistance in neoplastic cells /
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for re...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | , |
| Formato: | Electrónico Congresos, conferencias eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1988.
|
| Colección: | Bristol-Myers cancer symposia ;
9. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Mechanisms of drug resistance in neoplastic cells / |c edited by Paul V. Woolley III, Kenneth D. Tew. |
| 260 | |a San Diego : |b Academic Press, |c �1988. | ||
| 300 | |a 1 online resource (xxv, 390 pages) : |b illustrations | ||
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| 490 | 1 | |a Bristol-Myers cancer symposia ; |v 9 | |
| 500 | |a Proceedings of the Ninth Bristol-Myers Symposium on Cancer Research, held in Washington, D.C., on Oct. 15-16, 1986. | ||
| 504 | |a Includes bibliographical references and index. | ||
| 506 | |3 Use copy |f Restrictions unspecified |2 star |5 MiAaHDL | ||
| 533 | |a Electronic reproduction. |b [Place of publication not identified] : |c HathiTrust Digital Library, |d 2010. |5 MiAaHDL | ||
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| 588 | 0 | |a Print version record. | |
| 505 | 0 | |6 880-01 |a Front Cover; Mechanisms of Drug Resistance in Neoplastic Cells; Copyright Page; Table of Contents; Contributors; Editor's Foreword; Foreword; Preface; PART 1: General Considerations of Drug Resistance; Chapter 1. Colon Cancer as a Model for Resistance to Antineoplastic Drugs; I. Introduction; II. Types of Resistance: Intrinsic and Acquired; III. Clinical Resistance of Colon Cancer; IV. Behavior of Colon Cancer Cells in the Human Tumor Stem-Cell Assay; V. Effects of Radiation and Oxygen Radicals on Colon Carcinoma Cells; VI. A Model of Colon Cancer Resistance; VII. Circumventing Resistance. | |
| 505 | 8 | |a AcknowledgmentsReferences; Chapter 2. Mathematical Modeling of Drug Resistance; I. Introduction; II. A Model for the Appearance of a Single Resistant Phenotype; III. Implications of a Stem-Cell Model of Tumor Growth for the Acquisition of Drug Resistance; IV. Effect of Variability in the Mean Value of the Mutation Rate in the System; V. Effect of Treatment Sequencingand the Question of Dose intensity; VI. Partial Resistance; VII. Summary and Conclusions; References; Chapter 3. On the Mechanism of Induced Gene Amplification in Mammalian Cells; I. Introduction; II. Enhancement of the Frequ. | |
| 505 | 8 | |a III. Overreplication of DNA following Inhibition of DNA SynthesisIV. On the Mechanism of Overreplication of DNA; V. Overreplication-Recombination and the Generation of Amplifications and Chromosomal Aberrations-Mutations; VI. Consequences for Tumor Progressionand Chemotherapy Resistance; Acknowledgments; References; Chapter 4. Cellular Concomitants of Multidrug Resistance; I. Introduction; II. Plasma Membrane Glycoprotein(gp150-180/P-Glycoprotein); III. Chromosomal Organizationof Amplified MDRA Genes; IV. Low-Molecular-Weight Cytosolic Protein (Sorcin/V19); V. EGF Receptor. | |
| 505 | 8 | |a VI. Summary and OverviewAcknowledgments; References; Chapter 5. Resistance to Alkylating Agents:Basic Studies and Therapeutic Implications; I. Introduction; II. Development of Resistanceto Alkylating Agents; III. High-Dose Effect of Alkylating Agents-Experimental Model; IV. Cross-Resistance among Alkylating Agents; V. Resistance Mechanisms-Heterogeneity; VI. Other Studies of Resistance Mechanisms; VIII. Multilog Cell Kill for Alkylating Agents and Nonalkylating Agents against Sensitive Tumors; IX. Cross-Resistance among Alkylating Agents as Determined from Multilog Kill Analyses. | |
| 520 | |a Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C chan. | ||
| 650 | 0 | |a Cancer |x Chemotherapy |x Complications |v Congresses. | |
| 650 | 0 | |a Drug resistance in cancer cells |v Congresses. | |
| 650 | 0 | |a Pathology, Molecular |v Congresses. | |
| 650 | 0 | |a Drug resistance. | |
| 650 | 0 | |a Cancer |x Chemotherapy |x Complications |x Congresses. | |
| 650 | 0 | |a Drug resistance |v Congresses. | |
| 650 | 0 | |a Cancer cells |x Congresses. | |
| 650 | 0 | |a Pathology, Molecular |x Congresses. | |
| 650 | 2 | |a Antineoplastic Agents |x pharmacology |0 (DNLM)D000970Q000494 | |
| 650 | 2 | |a Drug Resistance |0 (DNLM)D004351 | |
| 650 | 2 | |a Neoplasms |x drug therapy |0 (DNLM)D009369Q000188 | |
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| 650 | 6 | |a Anticanc�ereux |0 (CaQQLa)201-0004692 |x Congr�es. |0 (CaQQLa)201-0378208 | |
| 650 | 6 | |a R�esistance aux m�edicaments |0 (CaQQLa)201-0079541 |v Congr�es. |0 (CaQQLa)201-0378219 | |
| 650 | 6 | |a Cellules canc�ereuses |0 (CaQQLa)201-0022186 |x Congr�es. |0 (CaQQLa)201-0378208 | |
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| 650 | 7 | |a MEDICAL |x Clinical Medicine. |2 bisacsh | |
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| 650 | 7 | |a MEDICAL |x Evidence-Based Medicine. |2 bisacsh | |
| 650 | 7 | |a MEDICAL |x Internal Medicine. |2 bisacsh | |
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| 650 | 7 | |a Pathology, Molecular |2 fast |0 (OCoLC)fst01054980 | |
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| 650 | 7 | |a Cancer |x Chimioth�erapie |x Congr�es. |2 ram | |
| 650 | 7 | |a Antibiotiques antin�eoplasiques |x Congr�es. |2 ram | |
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| 700 | 1 | |a Woolley, Paul V., |d 1939- | |
| 700 | 1 | |a Tew, Kenneth D. | |
| 711 | 2 | |a Bristol-Myers Symposium on Cancer Research |n (9th : |d 1986 : |c Washington, D.C.) | |
| 776 | 0 | 8 | |i Print version: |t Mechanisms of drug resistance in neoplastic cells. |d San Diego : Academic Press, �1988 |w (DLC) 87012656 |w (OCoLC)15791616 |
| 830 | 0 | |a Bristol-Myers cancer symposia ; |v 9. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780127633626 |z Texto completo |
| 880 | 8 | |6 505-01/(S |a X. Multilog Survival Analysis-Duration of Drug ExposureXI. Synergism; XII. Conclusions; References; Chapter 6. Phosphoprotein and ProteinKinase C Changes in Human Multidrug-Resistant Cancer Cells; I. Introduction; II. Human Breast Cancer Lines; III. Human Small-Cell Lung Cancer Lines; IV. Protein Kinase C; V. Conclusions; References; PART II: Enzymatic Basisof Drug Resistance; Chapter 7. Novel Drugs That Affect Glutathione Metabolism; I. Introduction; II. Summary of Glutathione Metabolismand Transport; III. Decrease of Cellular Glutathione by Inhibitionof γ-Glutamylcysteine Synthetase. | |