Hyaluronan in cancer biology /

Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tis...

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Bibliographic Details
Call Number:Libro Electrónico
Other Authors: Stern, Robert, M.D
Format: Electronic eBook
Language:Inglés
Published: San Diego, CA : Academic Press/Elsevier, 2009.
Edition:1st ed.
Subjects:
Hyaluronic acid > Pathophysiology.
Carcinogenesis.
Hyaluronic Acid > metabolism
Neoplasms > metabolism
Hyaluronan Receptors > metabolism
Disease Progression
Hyaluronic Acid > therapeutic use
Carcinogenesis
Acide hyaluronique > Physiopathologie.
Canc�erogen�ese.
MEDICAL > Oncology.
HEALTH & FITNESS > Diseases > Cancer.
Online Access:Texto completo
Table of Contents:
  • Association between cancer and "acid mucopolysaccharides" : an old concept comes of age, finally
  • Hyaluronan-CD44 interactions and chemoresistance in cancer cells
  • Growth factor regulation of hyaluronan deposition in malignancies
  • Hyaluronan binding protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development
  • CD44 meets Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of Merlin
  • Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression
  • Adhesion and penetration : two sides of CD44 signal transduction cascades in the context of cancer cell metastasis
  • Involvement of CD44, a molecule with a thousand faces, in cancer dissemination
  • RHAMM/HMMR : an itinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation
  • Altered hyaluronan biosynthesis in cancer progression.
  • Hyaluronidase : both a tumor promoter and suppressor
  • The hyaluronidases in cancer biology
  • Hyaluronan fragments : informational polymers commandeered by cancers
  • Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan
  • The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression
  • Hyaluronan synthesis and turnover in prostate cancer
  • Role of hyaluronan in melanoma progression
  • Role of hyaluronan metabolism in the initiation, invasion, and metastasis of breast cancer
  • Clinical use of hyaluronidase in combination cancer chemotherapy : a historic perspective
  • Exploring the hyaluronan:CD44 interaction for cancer therapy
  • Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that cause contagious respiratory tract cancers.

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