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Complex enzymes in microbial natural product biosynthesis. Part A, Overview articles and peptides /
Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compound...
| Call Number: | Libro Electrónico |
|---|---|
| Other Authors: | |
| Format: | Electronic eBook |
| Language: | Inglés |
| Published: |
Amsterdam ; Boston ; London : San Diego, Calif :
Elsevier ; Academic Press,
2009.
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| Edition: | 1st ed. |
| Series: | Methods in enzymology ;
v. 458. |
| Subjects: | |
| Online Access: | Texto completo Texto completo |
Table of Contents:
- Part 1: Overview articles<br><br>Introduction
- chemical classes of complex natural products and overview of their biosynthesis<br>Discovery of novel natural products<br>Trans-modification of intermediates on the assembly line in PKS, FAS and NRPS biosynthesis<br>Post-assembly line modifications, including glycosylation<br>Cloning and analysis of natural product pathways<br>In silico prediction of pathways from DNA sequence<br>Mass spectrometric analysis of PKS and NRPS biosynthetic intermediates<br>Synthetic probes for PKS and NRPS biochemistry<br>Directed evolution of natural products<br>Expression in a heterologous host<br>Pathway-specific and global regulation of antibiotic biosynthesis: <br>Regulation of antibiotic production by bacterial hormones:<br><br>Part 2: Peptides<br><br>A. Non-ribosomally-synthesised peptides<br><br>Overview of NRPSs, and mechanistic and structural studies<br>Siderophores<br>Cephamycins and clavulanic acid<br>Glycopeptides<br>Lipopeptides<br>Precursor Biosynthesis<br><br>B. Ribosomally synthesised peptides<br><br>Lantibiotic biosynthesis and engineering of novel compounds<br>Cyclic peptides from marine bacteria<br>