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Structural genomics. Part A /
Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any prote...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Oxford ; Burlington, MA :
Academic Press,
2008.
|
| Edición: | 1st ed. |
| Colección: | Advances in protein chemistry and structural biology ;
v. 75. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
MARC
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| 245 | 0 | 0 | |a Structural genomics. |n Part A / |c edited by Andrzej Joachimiak. |
| 250 | |a 1st ed. | ||
| 260 | |a Oxford ; |a Burlington, MA : |b Academic Press, |c 2008. | ||
| 300 | |a 1 online resource (ix, 153 pages) : |b illustrations (some color) | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Advances in protein chemistry and structural biology, |x 1876-1623 ; |v v. 75 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 520 | |a Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Introduction; Analysis of genomes for structural genomics and the limitations of sequence analysis; Structure determination pipeline for structural genomics;Gene cloning and protein expression;Gene cloning and expression of membrane proteins; High-throughput protein purification for x-ray crystallography and NMR; High-throughput protein crystallization; Structure determination using synchrotron radiation; Application of NMR to structural genomics; Development of key high-throughput technologies: High-throughput functional screening; Development of key high-throughput technologies: Structure prediction and homology modeling; Functional inferences from structure; Structural genomics programs (SARS case); Structural genomics programs (E.coli);Structural genomics as a structural foundation for drug discovery; Structural genomics of eukaryote; Structural genomics of complexes; Dissemination structural genomics data to biology community; ; | |
| 650 | 0 | |a Genomics. | |
| 650 | 0 | |a Proteins |x Structure. | |
| 650 | 6 | |a G�enomique. |0 (CaQQLa)201-0363181 | |
| 650 | 6 | |a Prot�eines |x Structure. |0 (CaQQLa)000300025 | |
| 650 | 7 | |a Genomics. |2 fast |0 (OCoLC)fst00940228 | |
| 650 | 7 | |a Proteins |x Structure. |2 fast |0 (OCoLC)fst01079759 | |
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| 700 | 1 | |a Joachimiak, Andrzej. | |
| 776 | 0 | 8 | |i Print version: |t Structural genomics |w (OCoLC)302061853 |
| 830 | 0 | |a Advances in protein chemistry and structural biology ; |v v. 75. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780123744364 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/18761623/75 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00653233 |z Texto completo |