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Advances in genetics : incorporating molecular genetics medicine. Volume 32 /
Volume 32 of Advances in Genetics: Incorporating Molecular Genetic Medicine focuses on important and fast moving subjects in modern human genetics and medicine. This volume also marks the new collaboration with Associate Editors Dr. Theodore Friedmann and Dr. Francesco Giannelli. Chapter 1 considers...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
�1995.
|
| Colección: | Advances in genetics ;
v. 32. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
Tabla de Contenidos:
- Front Cover; Advances in Genetics, Volume 32; Copyright Page; Contents; Contributors; Foreword; Preface; Chapter 1. After Gene Therapy: Issues in long-Term Clinical Follow-Up and Care; I. Introduction; II. Assessing the Long-Term Consequences of Somatic Gene Therapy; III. Ongoing Therapy for Adverse Experiences; IV. Ongoing Therapy for Clinical Benefit; V. Informed Consent for Follow-up; VI. Conclusion; References; Chapter 2. Gaucher Disease; I. Introduction; II. Clinical Manifestations of Disease; III. Molecular Biology; IV. Population Genetics; V. Treatment; VI. Unresolved Issues.
- VII. ControversiesReferences; Chapter 3. The Genetics of Non-insulin-Dependent Diabetes Mellitus; I. Introduction; II. Natural History of the Development of NIDDM; III. The Role of Genetic Factors in the Etiology of NIDDM; IV. Strategies for Identifying Diabetes-Susceptibility Genes in NIDDM; V. Candidate Genes; VI. The ""Thrifty"" Gene and Silent Polymorphism Hypotheses; VII. Conclusion; References; Chapter 4. The Hemophilias; I. Two Distinct Forms of Hemophilia; II. Genetics of the Hemophilias; III. Factor IX: The Gene and the Protein; IV. The Hemophilia B Mutations.
- V. Functional Interpretation of Observed Sequence Changes and Genotype/Phenotype Correlations in Hemophilia BVI. Progress in Carrier and Prenatal Diagnosis of Hemophilia B; VII. Factor VIII: The Gene and the Protein; VIII. Hemophilia A Mutations; IX. Functional Interpretation of Observed Sequence Changes and Genotype/Phenotype Correlations in Hemophilia A; X. Progress in Carrier and Prenatal Diagnosis in Hemophilia A; XI. Contribution of Molecular Biology to Treatment; XII. Conclusion; References.
- Chapter 5. The Influence of Molecular Biology on our Understanding of Lipoprotein Metabolism and the Pathobiology of AtherosclerosisI. Introduction; II. Background and Historical Perspective; III. Atherosclerosis Research in the Molecular Biology Era; IV. Summary and Future Directions; References; Chapter 6. Molecular Genetics of Phenylketonuria: From Molecular Anthropology to Gene Therapy; I. General Background; II. Characterization of the Human Phenylalanine Hydroxylase Gene; III. Molecular Genetics of PAH-Deficient PKU and Related HPAs; IV. Population Genetics of Phenylketonuria.
- V. Gene Therapy for PhenylketonuriaVI. Conclusions; References; Chapter 7. The Proterminal Regions and Telomeres of Human Chromosomes; I. Introduction; II. The Functions of Telomeres and Proterminal Regions; III. The Isolation and Structure of Human Telomeres; IV. The Structure of Proterminal Regions and Telomeres; V. Chromosome Ends from Other Primates; VI. The Role of Proterminal Regions and Telomeres in Senescence, Tumorigenesis, and Genetically Determined Diseases; VII. Conclusions; References; Index.