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Animal models in eye research /
The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms...
| Clasificación: | Libro Electrónico |
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| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego :
Academic Press,
2008.
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| Edición: | 1st ed. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- An introductory short chapter on the different types of eyes, stressing possible common molecular machinery (mono vs polyphyletic).
- Eye diversity in the animal Kingdom
- Photosensitivity: Melanopsin, opsins
- Cyanobacteria, protozoa: photoreception, rhodopsin
- Platynereis: as a model for lochotrophozoa
- Drosophila: Superb system for genetics, genetic manipulation.
- Planaria: As a model for invertebrate eye regeneration with emphasis on stem cells.
- Fish/cavefish: As a model for retina regeneration and lens development. Zebrafish is accessible for genetic manipulation by morpholinos, medaka accessible for genetic studies.
- Xenopus: As a model for retina (via progenitor cells) and lens regeneration (by transdifferentiation from the cornea). Also an important model for transgenic studies in amphibia.
- Newt: As a model for retina and lens regeneration in adult vertebrates by transdifferentiation. Xenopus and Newt could be combined as a chapter on amphibia.
- Chick: Excellent system for retina regeneration (both transdifferentiation and stem cells) as well for lens and retina development. RCAS transgenesis is an important asset of this system.
- Mouse: Knock-out and transgenesis technologies make this animal the best mammal to study eye development.
- Rabbit: Model for cataract surgery.
- A chapter could be devoted to animals where we see recruitment of crystallins to perform other roles
- Animal models for physiology of the eye.
- Anatomical and functional diversity of animal eyes
- The simplest eyes: rhodopsin-mediated phototaxis reception in microorganisms
- The planarian eye: a simple and plastic system with great regenerative capacity
- Development of the Drosophila melanogaster eye: from precursor specification to terminal differentiation
- The Antarctic toothfish: a new model system for eye lens biology
- Xenopus, an ideal vertebrate system for studies of eye development and regeneration
- The newt as a model for eye regeneration
- The chick as a model for retina development and regeneration
- Eye development using mouse genetics
- Epithelial explants and their application to study developmental processes in the lens
- Mouse models of the cornea and lens: understanding ocular disease
- Deciphering irradiance detection in the mammalian retina
- The rabbit in cataract/IOL surgery
- The primate in cataract/IOL surgery.