Cargando…
Regulators and effectors of small GTPases. Ras family / Volume 407 :
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission....
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
San Diego, California :
Elsevier/Academic Press,
�2006.
|
| Colección: | Methods in enzymology ;
v. 407. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo Texto completo |
MARC
| LEADER | 00000cam a2200000Ia 4500 | ||
|---|---|---|---|
| 001 | SCIDIR_ocm86174036 | ||
| 003 | OCoLC | ||
| 005 | 20231117014731.0 | ||
| 006 | m o d | ||
| 007 | cr cnu---unuuu | ||
| 008 | 070325s2006 cauaf ob 001 0 eng d | ||
| 040 | |a N$T |b eng |e pn |c N$T |d YDXCP |d OCLCQ |d YUM |d MERUC |d CUS |d E7B |d OCLCQ |d IDEBK |d OCLCQ |d OPELS |d OCLCQ |d OPELS |d OCLCF |d DEBBG |d KUK |d OCLCQ |d AU@ |d OCLCQ |d VVL |d OCLCQ |d TFH |d MERER |d OCLCO |d OCLCQ |d BUF |d OCLCO |d OCLCQ |d CRU |d OCLCQ |d ANS |d OCLCQ |d SOI |d OCLCQ |d OCLCO |d WURST |d OCLCA |d CUV |d OCLCO |d EBLCP |d UKDOC |d DEBSZ |d TXI |d OCLCA |d OCLCO |d OCLCQ |d OCLCO | ||
| 016 | 7 | |a 013365387 |2 Uk | |
| 019 | |a 70260150 |a 70841300 |a 154665011 |a 225211568 |a 437174744 |a 441763322 |a 476018403 |a 647618074 |a 814467969 |a 823136979 |a 823857092 |a 823927164 |a 824116803 |a 824168579 |a 871787571 |a 913498397 | ||
| 020 | |a 9780080463933 |q (electronic bk.) | ||
| 020 | |a 0080463932 |q (electronic bk.) | ||
| 020 | |a 0080463592 |q (electronic bk.) | ||
| 020 | |a 9780080463599 |q (electronic bk.) | ||
| 020 | |a 0121828123 |q (electronic bk.) | ||
| 020 | |a 9780121828127 |q (electronic bk.) | ||
| 020 | |a 1280635819 | ||
| 020 | |a 9781280635816 | ||
| 035 | |a (OCoLC)86174036 |z (OCoLC)70260150 |z (OCoLC)70841300 |z (OCoLC)154665011 |z (OCoLC)225211568 |z (OCoLC)437174744 |z (OCoLC)441763322 |z (OCoLC)476018403 |z (OCoLC)647618074 |z (OCoLC)814467969 |z (OCoLC)823136979 |z (OCoLC)823857092 |z (OCoLC)823927164 |z (OCoLC)824116803 |z (OCoLC)824168579 |z (OCoLC)871787571 |z (OCoLC)913498397 | ||
| 050 | 4 | |a QP601 |b .M49eb vol. 407 | |
| 060 | 4 | |a QU 25 |b C64 v.407 2006 | |
| 070 | |a QP601 |b .M49 v. 407 | ||
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 072 | 7 | |a K |2 bicssc | |
| 082 | 0 | 4 | |a 572.793 |2 22 |
| 245 | 0 | 0 | |a Regulators and effectors of small GTPases. |n Volume 407 : |b Ras family / |c edited by William E. Balch, Channing J. Der, Alan Hall. |
| 260 | |a San Diego, California : |b Elsevier/Academic Press, |c �2006. | ||
| 300 | |a 1 online resource (xliii, 780 pages, 18 unnumbered pages of plates) : |b illustrations. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a data file |2 rda | ||
| 490 | 1 | |a Methods in enzymology, |x 0076-6879 ; |v v. 407 | |
| 504 | |a Includes bibliographical references and indexes. | ||
| 505 | 0 | |a Ras and rap1 activation of plc[var epsilon] lipase activity / H. Edamatsu [and others] -- Specificity and expression of ralgps as ralgefs / L.A. Quilliam [and others] -- Biochemical and biological analyses of rgr ralgef oncogene / L.A. Martello [and others] -- Analysis of ras activation in living cells with gfp-rbd / T.G. Bivona [and others] -- Genetic and pharmacologic analyses of the role of icmt in ras membrane association and function / A.W. Svensson [and others] -- Characterization of the activation of the rap-specific exchange factor epac by cyclic nucleotides / H. Rehmann [and others] -- Biochemistry of the rap-specific guanine nucleotide exchange factors pdz-gef1 and -2 / H.B. Kuiperij [and others] -- Characterization of interactions between ras family gtpases and their effectors / P. RodriguezViciana [and others] -- Genetic and pharmacologic dissection of ras effector utilization in oncogenesis / P.M. Campbell [and others] -- Sequencing analysis of braf mutations in human cancers / R. Wooster [and others] -- Ksr regulation of the raf-mek-erk cascade / D.A. Ritt [and others] -- Ras-sensitive imp modulation of the raf/mek/erk cascade through ksr1 / S.A. Matheny [and others] -- Raf kinase inhibitor protein regulation of raf and mapk signaling / S. Hagan [and others] -- Harnessing rnai for analyses of ras signaling and transformation / A.W. Whitehurst [and others] -- The rac activator tiam1 and ras-induced oncogenesis / K. Strumane [and others] -- Phospholipase c[epsilon] guanine nucleotide exchange factor activity and activation of rap1 / T. Satoh [and others] -- Nore1 and rassf1 regulation of cell proliferation and of the mst1/2 kinases / J. Avruch [and others] -- Rassf family proteins and ras transformation / M.D. Vos [and others] -- Ras and the rain/rasip1 effector / N. Mitin [and others] -- The rin family of ras effectors / J.M. Bliss [and others] -- Rap1 regulation of riam and cell adhesion / E. Lafuente [and others] -- Regulation of cell-cell adhesion by rap1 / Y. Fujita [and others] -- Effects of ras signaling on gene expression analyzed by customized microarrays / O.I. Tchernitsa [and others] -- Protein-fragment complementation assays (pca) in small gtpase research and drug discovery / J.K. Westwick [and others] -- Ras up-regulation of cyclooxygenase-2 / M.G. Backlund [and others] -- Regulation of the expression of tropomyosins and actin cytoskeleton by ras transformation / G.L. Prasad [and others] -- Regulation of par-4 by oncogenic ras / K. Murthi Vasudevan [and others] -- Using drosophila and yeast genetics to investigate a role for the rheb gtpase in cell growth / P.H. Patel [and others]. | |
| 505 | 0 | |a (Contents continued) Biochemistry and biology of arhi (diras3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers / Y. Yu [and others] -- Gem protein signaling and regulation / Y. Ward [and others] -- Analyses of rem/rgk signaling and biological activity / D.A. Andres [and others] -- Analysis of rit signaling and biological activity / D.A. Andres [and others] -- Characterization of rerg: An estrogen-regulated tumor suppressor gene / M.D. Key [and others] -- Inhibition of transcription factor nf-[kappa]b activation by [kappa]b-ras / T. Huxford [and others] -- Analysis of rhes activation state and effector function / J. Bernal [and others] -- Rheb activation of mtor and s6k1 signaling / J. Hanrahan [and others] -- Use of retrovirus expression of interfering rna to determine the contribution of activated k-ras and ras effector expression to human tumor cell growth / A.T. Baines [and others] -- Using inhibitors of prenylation to block localization and transforming activity / A.C. Berzat [and others] -- Sorafenib (bay 43-9006, nexavar(r)), a dual-action inhibitor that targets raf/mek/erk pathway in tumor cells and tyrosine kinases vegfr/pdgfr in tumor vasculature / L. Adnane [and others] -- Yeast screens for inhibitors of ras-raf interaction and characterization of mcp inhibitors of ras-raf interaction / V. Khazak [and others] -- A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins / S.C. Kim [and others] -- A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro / K.M. O'Hayer [and others] -- Analysis of ras transformation of human thyroid epithelial cells / Z. Poghosyan [and others] -- Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer / D.G. Rosen [and others] -- Physiological analysis of oncogenic k-ras / P.A. PerezMancera [and others] -- Use of conditionally active ras fusion proteins to study epidermal growth, differentiation, and neoplasia / J.A. Reuter [and others] -- Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems / C. Agbunag [and others] -- Analyses of ras regulation of eye development in drosophila melanogaster / L.C. Firth [and others]. | |
| 588 | 0 | |a Print version record. | |
| 520 | |a The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. *Includes a database for Ras family proteins and their effectors and regulators *Complimentary to volume 406 coverage of the Rho family *Over 150 international contributors. | ||
| 650 | 0 | |a Guanosine triphosphatase. | |
| 650 | 0 | |a Ras proteins. | |
| 650 | 1 | 2 | |a GTP Phosphohydrolases |x physiology |0 (DNLM)D020558Q000502 |
| 650 | 1 | 2 | |a ras GTPase-Activating Proteins |x physiology |0 (DNLM)D020703Q000502 |
| 650 | 2 | 2 | |a ras Proteins |x metabolism |0 (DNLM)D018631Q000378 |
| 650 | 2 | |a GTP Phosphohydrolases |0 (DNLM)D020558 | |
| 650 | 2 | |a ras Proteins |0 (DNLM)D018631 | |
| 650 | 6 | |a GTPases. |0 (CaQQLa)201-0245840 | |
| 650 | 6 | |a Prot�eines ras. |0 (CaQQLa)201-0247764 | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biochemistry. |2 bisacsh | |
| 650 | 7 | |a Guanosine triphosphatase |2 fast |0 (OCoLC)fst00948750 | |
| 650 | 7 | |a Ras proteins |2 fast |0 (OCoLC)fst01090194 | |
| 650 | 1 | 7 | |a GTPasen. |2 gtt |
| 650 | 1 | 7 | |a Regelmechanismen. |2 gtt |
| 653 | 0 | 0 | |a glutathion transferase |
| 653 | 0 | 0 | |a glutathione transferase |
| 653 | 0 | 0 | |a regulatory genes |
| 653 | 1 | 0 | |a Proteins and Enzymes |
| 653 | 1 | 0 | |a Eiwitten en enzymen |
| 700 | 1 | |a Balch, William Edward, |d 1949- |e editor. | |
| 700 | 1 | |a Der, Channing J., |e editor. | |
| 700 | 1 | |a Hall, A. |q (Alan), |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Regulators and effectors of small GTPases. |d San Diego, California : Elsevier/Academic Press, �2006 |z 0121828123 |w (OCoLC)62760705 |
| 830 | 0 | |a Methods in enzymology ; |v v. 407. |x 0076-6879 | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780121828127 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00766879/407 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00766879 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/00766879/407 |z Texto completo |