Mendelian randomization : methods for using genetic variants in causal estimation /

Détails bibliographiques
Cote:Libro Electrónico
Auteurs principaux: Burgess, Stephen (Auteur), Thompson, Simon G. (Auteur)
Format: Électronique eBook
Langue:Inglés
Publié: Boca Raton, FL : Chapman & Hall/CRC, [2015]
Collection:Chap & Hall/CRC interdisciplinary statics series.
Sujets:
Medical genetics > Statistical methods.
Human genetics > Variation.
Mendelian Randomization Analysis > methods
Genetic Variation
Statistics as Topic > methods
Génétique médicale > Méthodes statistiques.
Variabilité génétique.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Human genetics > Variation
Medical genetics > Statistical methods
Accès en ligne:Texto completo (Requiere registro previo con correo institucional)
Table des matières:
  • Introduction and motivation
  • What is Mendelian randomization?
  • Assumptions for causal inference
  • Methods for instrumental variable analysis
  • Examples of Mendelian randomization analysis
  • Generalizability of estimates from Mendelian randomization
  • Weak instruments and finite-sample bias
  • Multiple instruments and power
  • Multiple studies and evidence synthesis
  • Example : the CRP CHD genetics collaboration
  • Future directions.

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