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Pharmaceutical formulation : the science and technology of dosage forms /

Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Tovey, Geoffrey D. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge : Royal Society of Chemistry, 2018
Colección:RSC drug discovery series ; 64.
Temas:
Acceso en línea:Texto completo

MARC

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245 0 0 |a Pharmaceutical formulation :  |b the science and technology of dosage forms /  |c editors: Geoffrey D. Tovey. 
264 1 |a Cambridge :  |b Royal Society of Chemistry,  |c 2018 
300 |a 1 online resource (409 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
490 1 |a RSC drug discovery series ;  |v 64 
500 |a Includes index. 
500 |a Title from title details screen. 
505 0 |a Intro; Title Page; Copyright Page; Preface; Contents; Chapter 1 Preformulation Studies; 1.1 Introduction; 1.2 Solubility; 1.2.1 Absolute (Intrinsic) Solubility; 1.2.2 Molecular Dissociation pKa; 1.2.3 Solubility in Various Solvents; 1.2.4 Solubility Rate (Dissolution); 1.3 Diffusion; 1.4 Partition Coefficient; 1.5 Permeability; 1.6 The Biopharmaceutical Classification System; 1.7 Moisture Uptake/Sorption; 1.7.1 Classification of Hygroscopicity; 1.8 Polymorphism and Crystallinity; 1.8.1 Differential Scanning Calorimetry (DSC); 1.8.2 Thermogravimetric Analysis (TGA) 
505 8 |a 1.8.3 Powder X-ray Diffraction1.8.4 Crystallinity; 1.9 Stability; 1.9.1 Chemical Degradation in Solution; 1.9.2 Hydrolytic Degradation; 1.9.3 Stability in Solvents Used in Formulation and/or Manufacture; 1.9.4 Dimerization and Polymerisation; 1.9.5 Photostability; 1.9.6 pH-dependent Stability; 1.9.7 Oxidative Stability; 1.9.8 Stability-Compatibility; 1.10 Solid-state Physico-Technical Properties; Further Reading; References; Chapter 2 Hard Capsules in Modern Drug Delivery; 2.1 Introduction; 2.2 Hard Capsules-Types, Characteristics and Applications 
505 8 |a 2.2.1 Hard Capsules as a Pharmaceutical Excipient2.2.2 Hard Capsules for Special Applications; 2.3 Selection of Capsules in Formulation Development; 2.4 Hard Capsule Drug Delivery Addressing Pharmaceutical Needs; 2.4.1 Hard Capsule Powder Blend Formulation and Processing; 2.4.2 Highly Potent and Low-dose Drug Formulations; 2.4.3 Enhancing Bioavailability of Poorly Aqueous Soluble Drugs; 2.4.4 Physical Modification of the Drug Substance; 2.5 Targeted Drug Delivery; 2.5.1 Capsules with Solid Formulation; 2.5.2 Abuse Deterrent; 2.6 Manufacture of Commercial Hard Capsules Products 
505 8 |a 2.6.1 Powder and Granule Blends2.6.2 Multiparticulates and Mini-tablets; 2.6.3 Tablet Filling; 2.6.4 Liquid and Semi-solid Formulation; 2.6.5 Powder Micro-dosing; 2.7 Conclusions; Acknowledgements; References; Chapter 3 Soft Capsules; 3.1 Introduction; 3.2 Background; 3.3 Technology Strengths/Limitations; 3.4 Description; 3.5 Equipment and Facilities; 3.6 Shell Components; 3.7 Fill Formulation; 3.8 Product Development; 3.8.1 Fill Formulation Development Processes; 3.8.2 Shell Compatibility; 3.8.3 Prototype Manufacture; 3.8.4 Process Development; 3.9 Clinical Supply 
505 8 |a 3.10 Analytical Considerations3.11 Excipient Considerations; 3.11.1 Gelatin; 3.11.2 Plasticizers; 3.11.3 Water; 3.11.4 Colors, Opacifiers etc.; 3.11.5 Ingredient Specifications; 3.12 Packaging and Stability Considerations; 3.13 Manufacturing Process; 3.14 Key Process and Product Parameters; 3.14.1 In-process Testing; 3.14.2 Set up (Pre-start); 3.14.3 During Encapsulation; 3.14.4 During Drying; 3.14.5 Finished Product; 3.15 Recent Technology Advances; 3.15.1 Film Coating; 3.15.2 Non-gelatin Shell and Controlled Release Fill; 3.15.3 Vaginal Dosage Forms; 3.16 Trends in Patent Activity 
520 |a Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. 
590 |a Knovel  |b ACADEMIC - Pharmaceuticals, Cosmetics & Toiletries 
650 0 |a Drugs  |x Dosage forms. 
650 2 |a Dosage Forms 
650 2 |a Drug Compounding 
650 6 |a Médicaments  |x Formes pharmaceutiques. 
650 7 |a MEDICAL  |x Pharmacology.  |2 bisacsh 
650 7 |a Drugs  |x Dosage forms  |2 fast 
650 7 |a Health and Wellbeing.  |2 ukslc 
700 1 |a Tovey, Geoffrey D.,  |e editor. 
830 0 |a RSC drug discovery series ;  |v 64. 
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