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The Construction of Analogy-Based Research Programs : the Lock-and-Key Analogy in 20th Century Biochemistry.
When the German chemist Emil Fischer presented his key-lock hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical struc...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Bielefeld :
Transcipt Verlag,
2019.
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| Colección: | Science studies.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover; Table of contents; Preface; 1 The lock-and-key analogy and its influence on 20th century biochemistry; 2 The lock-and-key analogy in Emil Fischer's program on sugar fermentation, 1890-1907; 3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930; 4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960; 5 Lock-and-key-based modeling and its influence on the development of biochemical research programs; 6 Concluding remarks on the construction of analogy-based research programs; Literature