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Discovering retroviruses : beacons in the biosphere /
When invading a host cell, viruses seize cell machinery to make copies of their own genes. The immune system recognizes the invasion. In contrast, retroviruses colonize host cells through the process of reverse transcriptase. Retroviruses open host cell DNA and graft in their retroviral RNA, integra...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, Massachusetts :
Harvard University Press,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Skalka, Anna Marie, |e author. | |
| 245 | 1 | 0 | |a Discovering retroviruses : |b beacons in the biosphere / |c Anne Marie Skalka. |
| 264 | 1 | |a Cambridge, Massachusetts : |b Harvard University Press, |c 2018. | |
| 264 | 4 | |c ©2018 | |
| 300 | |a 1 online resource (xi, 177 pages) : |b color illustrations, color map | ||
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| 520 | |a When invading a host cell, viruses seize cell machinery to make copies of their own genes. The immune system recognizes the invasion. In contrast, retroviruses colonize host cells through the process of reverse transcriptase. Retroviruses open host cell DNA and graft in their retroviral RNA, integrating into the host genome. The immune system has difficulty recognizing or ridding of foreign DNA that has become its own. Discovering Retroviruses presents the history of retrovirus discovery. Skalka illuminates retroviruses' role in evolution, human health, and disease, from the first sighting at the end of the nineteenth century to recent use in genetic engineering. Retroviral sequences in the human genome mark sites where endogenous retrovirus integrated over six million years ago. The 100,000 pieces of retrovirus DNA are remnants from germ line cell invasions and total approximately eight percent of the human genome. Through investigation of animal and human retroviral sequences, we know retroviral mutations can lead to cancers and immunodeficiencies, including HIV and leukemia. Today, researchers harness retroviruses for use in gene delivery systems and precision medicine advances. Discovering Retroviruses offers a lively perspective on stories of the major pioneers of the past century and the extraordinary roads to their discoveries, and demonstrates the growing importance of genetics to modern biomedicine.-- |c Provided by publisher. | ||
| 504 | |a Includes bibliographical references (pages 161-170) and index. | ||
| 505 | 0 | |a Early pioneers -- Amending the central dogma -- The origin of retroviruses -- Retroviruses and evolution -- Revealing the genetic basis of cancer -- HIV and the AIDS pandemic. | |
| 588 | 0 | |a Print version record. | |
| 590 | |a JSTOR |b Books at JSTOR Demand Driven Acquisitions (DDA) | ||
| 590 | |a JSTOR |b Books at JSTOR All Purchased | ||
| 650 | 0 | |a Retroviruses. | |
| 650 | 0 | |a Retrovirus infections. | |
| 650 | 0 | |a Viruses |x Evolution. | |
| 650 | 0 | |a Medicine |x Research |x History. | |
| 650 | 0 | |a Medicine |x History. | |
| 650 | 2 | |a Retroviridae | |
| 650 | 2 | |a Retroviridae Infections | |
| 650 | 2 | |a Viruses |x growth & development | |
| 650 | 2 | |a History of Medicine | |
| 650 | 6 | |a Rétrovirus. | |
| 650 | 6 | |a Infections à rétrovirus. | |
| 650 | 6 | |a Virus |x Évolution. | |
| 650 | 6 | |a Médecine |x Recherche |x Histoire. | |
| 650 | 6 | |a Médecine |x Histoire. | |
| 650 | 7 | |a history of medicine. |2 aat | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Biology. |2 bisacsh | |
| 650 | 7 | |a SCIENCE |x Life Sciences |x Microbiology. |2 bisacsh | |
| 650 | 7 | |a Medicine |2 fast | |
| 650 | 7 | |a Medicine |x Research |2 fast | |
| 650 | 7 | |a Retrovirus infections |2 fast | |
| 650 | 7 | |a Retroviruses |2 fast | |
| 650 | 7 | |a Viruses |x Evolution |2 fast | |
| 655 | 7 | |a History |2 fast | |
| 776 | 0 | 8 | |i Print version: |a Skalka, Anna M. |t Discovering retroviruses. |d Cambridge, Massachusetts : Harvard University Press, 2018 |z 9780674971707 |w (DLC) 2018002504 |w (OCoLC)1023054801 |
| 856 | 4 | 0 | |u https://jstor.uam.elogim.com/stable/10.2307/j.ctv24w62t8 |z Texto completo |
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