Adaptive oncogenesis : a new understanding of how cancer evolves inside us /

"Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in th...

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Bibliographic Details
Call Number:Libro Electrónico
Main Author: DeGregori, James (Author)
Format: Electronic eBook
Language:Inglés
Published: Cambridge, Massachusetts : Harvard University Press, 2018.
Subjects:
Carcinogenesis.
Cells > Evolution.
Cancer > Etiology.
Cancer > Genetic aspects.
Carcinogenesis
Neoplasms > etiology
Neoplastic Processes
Genetic Predisposition to Disease
Cancérogenèse.
Cellules > Évolution.
Cancer > Étiologie.
Cancer > Aspect génétique.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
SCIENCE / Life Sciences / Evolution
Online Access:Texto completo
Table of Contents:
  • The evolution of lifespans and disease avoidance
  • Understanding evolution at organismal and somatic levels
  • The evolution of multicellularity and tumor suppression
  • Mechanisms of tumor suppression
  • Dominant views on the mechanisms of oncogenesis
  • Adaptive oncogenesis
  • Limiting somatic evolution in youth
  • Changing adaptive landscapes in aging tissues
  • Changing adaptive landscapes with carcinogenic exposures
  • Tissue architecture and tumor suppression
  • Peto's paradox
  • Prolonging tissue maintenance to delay aging and cancer
  • Understanding clinical data from an evolutionary perspective
  • The causes of cancer in early childhood
  • Evolution-informed strategies to combat cancer
  • A new framework for understanding and controlling cancer.

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