Integrated cardiac safety assessment methodologies for noncardiac drugs in discovery, development, and postmarketing surveillance /

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Détails bibliographiques
Cote:Libro Electrónico
Auteur principal: Turner, J. Rick
Autres auteurs: Durham, Todd A.
Format: Électronique eBook
Langue:Inglés
Publié: Hoboken, N.J. : John Wiley & Sons, c2009.
Sujets:
Cardiovascular toxicology.
Heart > Effect of drugs on.
Drugs > Side effects > Testing.
Drugs > Safety measures.
Electronic books.
Accès en ligne:Texto completo
Table des matières:
  • The importance of cardiac safety assessments
  • The biological basis of adverse drug reactions
  • Cardiac structure and function
  • Cardiac pathophysiology and disease
  • Drug discovery and drug design
  • Nonclinical development
  • The thorough QT/QTc trial
  • General safety assessments
  • Therapeutic use trials and meta-analyses
  • Assessment methodologies in nonexperimental postmarketing surveillance
  • Postmarketing proarrhythmic cardiac safety assessments
  • Generalized cardiac safety
  • Medication errors, adherence, and concordance
  • Future directions in drug safety.

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