Genetherapy

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Kartan, Preethi
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Ashland : Delve Publishing, 2020.
Temas:
Gene therapy.
Genetic Therapy
Thérapie génique.
Gene therapy
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Cover
  • Title Page
  • Copyright
  • DECLARATION
  • ABOUT THE EDITOR
  • TABLE OF CONTENTS
  • List of Contributors
  • List of Abbreviations
  • Preface
  • Chapter 1 Recent Advances in the Development of Gene Delivery Systems
  • Abstract
  • Background
  • Conclusion
  • References
  • Chapter 2 Cell Penetrating Peptides, Novel Vectors for Gene Therapy
  • Abstract
  • Introduction
  • Types of CPPs
  • Identification of Tissue Specific CPPs
  • Mechanisms of Transduction
  • Cell Penetrating Peptides as Gene Delivery Vectors
  • Hurdles to Clinical Application
  • Summary
  • Patents
  • Author Contributions
  • Funding
  • Acknowledgments
  • Conflicts of Interest
  • References
  • Chapter 3 Advances in Viral Vector-Based TRAIL Gene Therapy for Cancer
  • Abstract
  • Introduction: Trail As An Anti-Cancer Biologic Agent
  • Structure And Function of Trail
  • The Trail Receptor Family
  • Signaling Cascades That Regulate Trail-Induced Apoptosis
  • Overcoming Tumor Cell Resistance To Trail-Induced Apoptosis
  • Viral Vector-Mediated Gene Therapy
  • Conclusions
  • Acknowledgements
  • References
  • Chapter 4 Advances in Lipid Nanoparticles for siRNA Delivery
  • Abstract
  • Introduction
  • LNP Formulation: Composition, Structure And Size
  • Encapsulation And Intracellular Release: Dual Function of Ionizable Amino Lipids
  • Steric Barrier: Stability and Circulation Lifetime
  • Cellular Uptake: Endogenous and Exogenous Targeting Ligands
  • Concluding Remarks
  • Acknowledgments
  • Conflicts Of Interest
  • References
  • Chapter 5 Gene Switches for Deliberate Regulation of Transgene Expression: Recent Advances in System Development and Uses
  • Abstract
  • Introduction
  • Small Molecule-Dependent Gene Switches
  • Transgene Activation By Focused Heat or Ionizing Radiation
  • Other Inducible Systems
  • Concluding Remarks
  • References
  • Chapter 6 Simultaneous Administration of ADSCs-Based Therapy and Gene Therapy Using Ad-huPA Reduces Experimental Liver Fibrosis
  • Abstract
  • Introduction
  • Materials And Methods
  • Results
  • Discussion
  • Conclusions
  • Funding Statement
  • Data Availability
  • References
  • Chapter 7 Gene Therapy: Advances, Challenges and Perspectives
  • Abstract
  • Introduction
  • Comment
  • References
  • Chapter 8 Recent Advances in Mitochondria-Targeted Gene Delivery
  • Abstract
  • Introduction
  • Physical Approaches
  • Chemical Approaches
  • Biological Approaches
  • Combinatorial Approaches
  • Cargo Dnas
  • Applications As Disease Therapies
  • Concluding Remarks
  • Funding
  • Conflicts Of Interest
  • References
  • Chapter 9 Gene Therapy for Cancer: Present Status and Future Perspective
  • Abstract
  • Introduction
  • History
  • Methods Of Gene Therapy
  • Gene Transfer Delivery System
  • Gene Therapy Implementation
  • Immunomodulation
  • Innate Immunity
  • Immunomodulatory Approaches In Cancer Therapy
  • Other Gene Therapy Approaches In Cancer Management
  • Problems With Gene Therapy
  • Review, Conclusions
  • Authors' Information

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