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Systems thinking in medicine and new drug discovery. Volume one /
Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encoura...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Newcastle upon Tyne :
Cambridge Scholars Publishing,
2018.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Intro; Contents; Preface; Chapter One; 1.1 Introduction; 1.2 Reductionist Thinking and DNA; 1.3 Systems Thinking; 1.3.1 Definition and the importance of change; 1.3.2 Misconceptions that are clarified by systems thinking; 1.3.3 Characteristics of systems thinking; 1.3.4 The roots of systems thinking; 1.3.5 Autopoiesis and Gaia; 1.3.6 Systems view of autopoiesis and stem cells; 1.3.7 The importance of networks in life; 1.3.8 Genetics and systems thinking; 1.3.9 Nonlinearity and rhythms in living systems; 1.3.10 The -omics, from genomics to personal -omics
- 1.3.11 A multidimensional, non-linear view of diseases1.3.12 Drugs that bind to multiple targets; 1.3.13 Modularity of biological networks; 1.3.14 Going beyond genomics and looking for hidden connections; 1.3.15 Tools for understanding metabolism better; 1.3.16 Evidence based medicine and the Critical Path Initiative; 1.3.17 Cancer Genome Characterization Initiative, CGCI; 1.3.18 Systems-based thinking in education, in contrast with reductionist thinking inadvertisements and propaganda; 1.4 More systems thinking is needed; 1.5 Reductionist thinking is still useful; References; Chapter Two
- 2.1 The human ecosystem, holobionts, hologenome and viruses2.2 The widespread existence of microbes in the human body; 2.3 Gut microbiome and the enteric nervous system (ENS; 2.3.1 Composition of the gut micr; 2.3.2 Interactions and communication between the ENS and the rest of the body; 2.3.3 Communication between the gut microbiome, ENS, brain and immune system; 2.3.4 The gut microbiota and ENS comprise an entero endocrine organ; 2.4 The role of the gut microbiome in preventing diseases; 2.5 The role of gut microbiome dysbiosis in causing diseases; 2.5.1 The importance of biodiversity
- 2.5.2 The gut microbiome and inflammation2.5.3 The benefits of vegan and vegetarian diets; 2.5.4 The gut microbiome and cardiovascular diseases; 2.5.5 The role of the gut microbiome in stress, anxiety and neurodegenerative diseases; 2.5.6 The importance of healthy microbiota in obtaining an effective response to vaccines; 2.5.7 The importance of oral health and preventing periodontal disease; 2.6 Factors affecting the composition of the microbiome; 2.7 Viruses are important, too; 2.8 Eukarya in the human microbiome; 2.8.1 Introduction to the microbial eukaryotic cells in the human microbiome
- 2.8.2 Fungi2.8.3 Protozoa and intestinal worms (helminths); References; Chapter Three; 3.1 How new drugs are developed; 3.1.1 Select a Disease; 3.1.2 Select a therapeutic target or phenotype; 3.1.3 Find a lead compound; 3.1.4 Improve the lead compound; 3.1.5 Drug delivery; 3.1.6 Manufacturing and cGMP; 3.1.7 Clinical trials; 3.1.8 Many drugs that were developed and approved had a single therapeutic target; 3.1.9 Combinations of drugs are also used and are being developed; 3.1.10 Some targets are now known to have formerly unexpected biological roles