Translational neuroscience : toward new therapies /

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Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics...

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Détails bibliographiques
Cote:Libro Electrónico
Autres auteurs: Nikolich, Karoly, Hyman, Steven E.
Format: Électronique eBook
Langue:Inglés
Publié: Cambridge, MA : The MIT Press, [2015]
Collection:Strüngmann Forum reports.
Sujets:
Neurosciences > Research.
Nervous system > Diseases.
Drug development.
Nervous System Diseases > therapy
Translational Research, Biomedical
Models, Animal
Nervous System Diseases
Neurosciences > Recherche.
Système nerveux > Maladies.
Médicaments > Développement.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Drug development
Nervous system > Diseases
Neurosciences > Research
NEUROSCIENCE/General
BIOMEDICAL SCIENCES/General
Congress
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Accès en ligne:Texto completo
Table des matières:
  • Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1
  • Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2
  • What Do We Know about Early Onset Neurodevelopmental Disorders?; 3
  • Psychotic Disorders and the Neurodevelopmental Continuum; 4
  • Neurodevelopmental Disorders; 5
  • Neurodegenerative Diseases; 6
  • Preclinical and Clinical Understanding; 7
  • Neurodegenerative Diseases.
  • 8
  • How Might We Get from Genes to Circuits to Disease?9
  • How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10
  • Pathophysiological Toolkit; 11
  • Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12
  • From Rodent Behavioral Models to Human Disorders; 13
  • Bridging the Gap between Patients and Models; 14
  • The Revolution Has Begun.

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