Affinity and efficacy : the components of drug-receptor interactions /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Ehlert, Frederick J. (Autor)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New Jersey : World Scientific, [2014]
Temas:
Drug receptors.
Drugs > Effectiveness.
Drug-nutrient interactions.
Pharmaceutical chemistry.
Carrier proteins.
Radioligand assay.
Receptors, Drug
Food-Drug Interactions
Chemistry, Pharmaceutical
Ligand-Gated Ion Channels
Carrier Proteins
Radioligand Assay
Receptors, G-Protein-Coupled
Récepteurs de médicaments.
Médicaments > Efficacité.
Interactions médicaments-aliments.
Chimie pharmaceutique.
Protéines de liaison.
Dosage radiocompétitif.
MEDICAL > Pharmacology.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Ligand-gated ion channels
  • Affinity and efficacy of orthosteric ligands at ligand-gated ion channels
  • Competitive interactions between orthostheric ligands at ligand-gated ion channels
  • Analysis of allosteric interactions at ligand-gated ion channels
  • G protein-coupled receptors and G protein signaling
  • Affinity and efficacy of the agonist-receptor-G-protein interaction
  • Estimating affinity and efficacy by reverse-engineering and response-clamp analysis
  • Analysis of agonism and inverse agonism in signaling pathways that exhibit constitutive activity
  • Analysis of ligand bias in receptor signaling through different G protein pathways
  • Competitive interactions between orthosteric ligands in functional assays on G protein-coupled receptors
  • Analysis of allosterism in functional assays on G protein-coupled receptors
  • Analysis of drug-receptor interactions using radioligand binding assays on G protein-coupled receptors.

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