Cargando…

Cardiac mechano-electric coupling and arrhythmias /

Ranging from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction, this new edition offers a thoroughly reviewed compendium of chapters, written by the top-experts in the world on the mechanism and consequences of cardiac mechano...

Descripción completa

Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Kohl, Peter, MD
Otros Autores: Sachs, Frederick, Franz, M. R. (Michael R.), 1949-
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Oxford ; New York : Oxford University Press, 2011.
Edición:2nd ed.
Temas:
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Basic science, section I: sub-cellular mechanisms of cardiac mechano-electric coupling
  • Evolutionary origins of stretch-activated ion channels
  • Stretch-activated channels in the heart
  • The mechano-gated K2P channel TREK-1 in the cardiovascular system
  • Cell volume-sensitive ion channels and transporters in cardiac myocytes
  • The response of cardiac muscle to stretch: calcium and force
  • Stretch effects on second messengers
  • Functional implications of myocyte architecture
  • Mechanical modulation of pacemaker electrophysiology
  • Mechano-electric coupling in working cardiomyocytes: diastolic and systolic effects
  • Mechano-sensitivity of pulmonary vein cells: implications for atrial arrhythmogenesis
  • Heterogeneity of sarcomere length and function as a cause of arrhythmogenic calcium waves
  • Cellular mechanisms of arrhythmogenic cardiac alternans
  • Remodeling of gap junctions in ventricular myocardium: effects of cell-to-cell adhesion, mediators of hypertrophy and mechanical forces
  • The origin of fibroblasts, ECM and potential contributions to cardiac mechano-electric coupling
  • Advantages and pitfalls of cell cultures as model systems to study cardiac mechanoelectric coupling
  • Activation sequence of cardiac muscle in simplified experimental models: relevance for cardiac mechano electric coupling
  • Acute stretch effects on atrial electro-physiology
  • Stretch effects on potassium accumulation and alternans in pathological myocardium
  • The effects of wall stretch on ventricular conduction and refractoriness in the whole heart
  • Mechanical triggers of long-term ventricular electrical remodeling
  • Mechanisms of mechanical pre- and postconditioning
  • Mechano-electric coupling in chronic atrial fibrillation
  • Mechanically induced pulmonary vein ectopy
  • insight from animal models
  • Regional variation in mechano-electric coupling: the right ventricle
  • Mechanical induction of arrhythmia in the ex-situ heart: insight into commotio cordis
  • Arrhythmias in murine models of the mechanically impaired heart
  • Studying cardiac mechano-sensitivity in man
  • Mathematical models of cardiac structure and function: mechanistic insights from models of heart failure
  • Mathematical models of human atrial mechano-electrical coupling and arrhythmias
  • Mathematical models of ventricular mechano-electric coupling and arrhythmia
  • Load dependence of ventricular repolarisation
  • Is the U wave in the electrocardiogram a mechanoelectrical phenomenon?
  • Mechanical modulation of cardiac function: role of the pericardium
  • Mechanically-induced electrical remodelling in human atrium
  • Drug effects and atrial fibrillation: potential and limitations
  • Stretch as a mechanism linking short- and long-term electrical remodeling in the ventricles.
  • Volume and pressure overload and ventricular arrhythmogenesis
  • Stretch effects on fibrillation dynamics
  • Commotio cordis: sudden death from blows to the chest wall
  • Repolarization changes in the synchronously and dys-synchronously contracting failing heart
  • Ventricular arrhythmias in heart failure: link to hemodynamic load
  • Mechanical heterogeneity and aftercontractions as trigger of torsades des pointes
  • Stretch-induced arrhythmias in ischaemia
  • Antiarrhythmic effects of acute mechanical stimulation
  • Termination of arrhythmias by haemodynamic unloading
  • Mechanical modulation of defibrillation and resuscitation efficacy
  • Anti- and pro-arrhythmic effects of cardiac assist device implantation
  • Anti- and pro-arrhythmic effects of cardiac resynchronization therapy
  • Evidence for mechano-electric coupling from clinical trials on AF
  • Evidence for mechano-electric coupling from clinical trials in heart failure
  • Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy
  • Evidence for mechano-electric coupling from clinical trials on cardiac resynchronization therapy
  • Mechano-electric coupling in patients treated with ventricular assist devices: insights from individual cases and clinical trials
  • Measuring strain of structural proteins in vivo in real time
  • Roles of SAC beyond M-E transaction
  • Distributions of myocyte stress, strain and work in normal and infarcted ventricles
  • Evolving concepts in measuring ventricular strain in the canine and human hearts: non-invasive imaging
  • Evolving concepts in measuring ventricular strain in the human heart: impedance measurements
  • Mechanosensitive channel blockers: a new class of antiarrhythmic drugs?