Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition /

Antibiotic-resistant bacteria, or "superbugs," present an increasingly deadly threat to human health. With chapters from the world's leading researchers and scholars in this field, this comprehensive volume is a vital and timely overview of this critical subject.

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bonomo, Robert A. (Editor ), Tolmasky, Marcelo (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington, D.C. : ASM Press, ©2007.
Temas:
Drug resistance in microorganisms.
Drug resistance in microorganisms > Genetic aspects.
Microbial enzymes.
Enzyme inhibitors.
Anti-Bacterial Agents
Drug Resistance, Bacterial
Enzyme Inhibitors
beta-Lactamase Inhibitors
Enzymes microbiennes.
Bactéries pathogènes > Résistance aux médicaments.
Antienzymes.
HEALTH & FITNESS > Diseases > General.
MEDICAL > Clinical Medicine.
MEDICAL > Diseases.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Internal Medicine.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Overview of aminoglycosides and enzyme-mediated bacterial resistance: clinical implications / Robert A. Bonomo
  • Aminoglycoside antibiotics / Kanchana Majumder [and others]
  • Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis
  • Aminoglycoside-modifying enzymes: characteristics, localization, and dissemination / Marcelo E. Tolmasky
  • rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts
  • [Beta]-lactamases: historical perspectives / Karen Bush and Patricia A. Bradford
  • Resistance mediated by penicillin-binding proteins / Malcolm G.P. Page
  • Inhibition of class A [beta]-lactamases / Samy O. Meroueh, Jooyoung Cha, And Shahriar Mobashery
  • Class B [beta]-lactamases / Gian Maria Rossolini and Jean-Denis Docquier
  • Crystal structures of class C [beta]-lactamases: mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters.
  • Class D [beta]-lactamases / Franck Danel, Malcolm G.P. Page, and David M. Livermore
  • Kinetics of [beta]-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Frère
  • The pharmaceutical industry and inhibitors of bacterial enzymes: implications for drug development / David M. Shlaes, Lefa Alksne, and Steven J. Projan
  • [Beta]-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill
  • Active drug efflux in bacteria / Jürg Dreier
  • Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky
  • Conjugative transposons / Louis B. Rice
  • The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters
  • Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso [and others]
  • Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer
  • The biological cost of antibiotic resistance / Dan I. Andersson [and others].

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