Overcoming challenges to develop countermeasures against aerosolized bioterrorism agents : appropriate use of animal models /

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The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testi...

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Détails bibliographiques
Cote:Libro Electrónico
Collectivités auteurs: National Research Council (U.S.). Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents, National Research Council (U.S.). Board on Life Sciences, Institute for Laboratory Animal Research (U.S.)
Format: Électronique eBook
Langue:Inglés
Publié: Washington D.C. : National Academies Press, ©2006.
Sujets:
Bioterrorism > Research.
Chemical warfare.
Toxicity testing.
Toxicology.
Toxicology > Animal models.
Aerosols > toxicity [mesh]
Bioterrorism [MESH]
Chemical Warfare
Toxicology
Models, Animal [MESH]
Research [MESH]
Bioterrorisme > Recherche.
Guerre chimique.
Toxicologie.
Toxicologie > Modèles animaux.
toxicology.
MEDICAL > Toxicology.
Accès en ligne:Texto completo
Description
Résumé:The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies -- including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) -- be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.
Description matérielle:1 online resource (xvi, 71 pages) : illustrations, charts (some color)
Bibliographie:Includes bibliographical references.
ISBN:9780309660938
0309660939
1280567406
9781280567407
9786610567409
6610567409

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