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|a UAMI
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|a Bioprocessing technology for production of biopharmaceuticals and bioproducts /
|c edited by Claire Komives, Weichang Zhou.
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|a First edition.
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264 |
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|a Hoboken, NJ :
|b John Wiley & Sons, Inc.,
|c 2019.
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300 |
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|a 1 online resource (xiii, 273).
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336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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490 |
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|a Wiley series in biotechnology and bioengineering
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|a Includes bibliographical references and index.
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520 |
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|a "Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries Includes illustrative case studies that review six milestone bio-products Discusses a wide selection of host strain types and disruptive bioprocess technologies"--Provided by publisher
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|a Print version record and CIP data provided by publisher; resource not viewed.
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|a Cover; Title Page; Copyright; Contents; List of Contributors; Part I Case Study; Chapter 1 Bacillus and the Story of Protein Secretion and Production; 1.1 Bacillus as a Production Host: Introduction and Historical Account; 1.2 The Building of a Production Strain: Genetic Tools for B. subtilis Manipulation; 1.2.1 Promoters; 1.2.2 Vectors for Building a Production Strain; 1.2.3 B. subtilis Competent Cell Transformation; 1.2.4 Protoplasts-Mediated Manipulations; 1.2.5 Genetics by Electroporation; 1.3 B. subtilis Secretion System and Heterologous Protein Production
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|a 1.3.1 Bacillus Fermentation and Recovery of Industrial Enzyme1.3.2 Fermentation Stoichiometry; 1.3.3 Fermentor Kinetics and Outputs; 1.3.4 Downstream Processing; 1.4 Summary; References; Chapter 2 New Expression Systems for GPCRs; 2.1 Introduction; 2.2 Recombinant GPCR Production -- Traditional Approaches for Achieving High-Level Production; 2.3 Engineered Expression Systems for GPCR Production; 2.3.1 Bacteria; 2.3.2 Yeasts; 2.3.3 Insect Cells; 2.3.4 Mammalian Cells; 2.3.5 Transgenic Animals; 2.3.6 Cell-Free Systems; 2.4 Conclusion; References; Chapter 3 Glycosylation; 3.1 Introduction
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|a 3.2 Types of Glycosylation3.2.1 N-linked Glycans; 3.2.2 O-linked Glycans; 3.3 Factors Affecting Glycosylation; 3.3.1 Nutrient Depletion; 3.3.2 Fed-batch Cultures and Supplements; 3.3.3 Specific Culture Supplements; 3.3.4 Ammonia; 3.3.5 pH; 3.3.6 Oxygen; 3.3.7 Host Cell Systems; 3.3.8 Other Factors; 3.4 Modification of Glycosylation; 3.4.1 siRNA and Gene Knockout/Knockin; 3.4.2 Glycoprotein Processing Inhibitors and In Vitro Modification of Glycans; 3.5 Glycosylation Analysis; 3.5.1 Release of Glycans from Glycoproteins; 3.5.2 Derivatization of Glycans; 3.6 Methods of Analysis
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|a 3.6.1 Lectin Arrays3.6.2 Liquid Chromatography; 3.6.2.1 HILIC Analysis; 3.6.2.2 Reversed Phase (RP) and Porous Graphitic Carbon (PGC) Chromatography; 3.6.2.3 Weak Anion Exchange (WAX) HPLC Analysis; 3.6.2.4 High pH Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC-PAD); 3.6.3 Capillary Electrophoresis (CE); 3.6.4 Fluorophore-assisted Carbohydrate Electrophoresis (FACE) and CGE-LIF; 3.6.5 Mass Spectrometry (MS); 3.6.5.1 Ionization; 3.6.5.2 Derivatization Techniques Used for MS Analysis of Glycans; 3.6.5.3 Fragmentation of Carbohydrates; 3.7 Conclusion; References
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|a Part II BioreactorsChapter 4 Bioreactors for Stem Cell and Mammalian Cell Cultivation; 4.1 Overview of (Mammalian and Stem) Cell Culture Engineering; 4.1.1 Cell Products for Therapeutics; 4.1.2 Cell as a Product: Stem Cells; 4.2 Bioprocess Characterization; 4.2.1 Cell Cultivation Methods; 4.2.2 Cell Metabolism; 4.2.3 Culture Medium Design; 4.2.4 Culture Parameters; 4.2.5 Culture Modes; 4.3 Cell Culture Systems; 4.3.1 Static Culture Systems; 4.3.2 Roller Bottles; 4.3.3 Spinner Flask; 4.3.4 Airlift Bioreactor; 4.3.5 Fixed/Fluidized-Bed Bioreactor; 4.3.6 Wave Bioreactor
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590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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650 |
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0 |
|a Pharmaceutical biotechnology industry.
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650 |
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0 |
|a Biotechnological process monitoring.
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650 |
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|a Pharmaceutical technology.
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650 |
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|a Bioreactors.
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1 |
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|a Biological Products
|x chemistry
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|a Drug Compounding
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2 |
|a Technology, Pharmaceutical
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650 |
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|a Bioreactors
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6 |
|a Biotechnologie pharmaceutique
|x Industrie.
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6 |
|a Procédés biotechnologiques
|x Surveillance.
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|a Techniques pharmaceutiques.
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6 |
|a Bioréacteurs.
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650 |
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|a MEDICAL
|x Pharmacology.
|2 bisacsh
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|a Pharmaceutical technology
|2 fast
|
650 |
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7 |
|a Bioreactors
|2 fast
|
650 |
|
7 |
|a Biotechnological process monitoring
|2 fast
|
650 |
|
7 |
|a Pharmaceutical biotechnology industry
|2 fast
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700 |
1 |
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|a Komives, Claire,
|e editor.
|
700 |
1 |
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|a Zhou, Weichang,
|d 1963-
|e editor.
|
758 |
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|i has work:
|a Bioprocessing technology for production of biopharmaceuticals and bioproducts (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGdPQhKHB3th6qTXhy43pK
|4 https://id.oclc.org/worldcat/ontology/hasWork
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776 |
0 |
8 |
|i Print version:
|t Bioprocessing technology for production of biopharmaceuticals and bioproducts.
|b First edition.
|d Hoboken, NJ : John Wiley & Sons, Inc., 2018
|z 9781118361986
|w (DLC) 2018036496
|
830 |
|
0 |
|a Wiley series in biotechnology and bioengineering.
|
856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=5612900
|z Texto completo
|
938 |
|
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|a ProQuest Ebook Central
|b EBLB
|n EBL5612900
|
938 |
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|a EBSCOhost
|b EBSC
|n 1985274
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994 |
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|a 92
|b IZTAP
|