Therapeutic development in the absence of predictive animal models of nervous system disorders : proceedings of a workshop /

Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about t...

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Bibliographic Details
Call Number:Libro Electrónico
Main Author: Bain, Lisa J. (rapporteur.)
Corporate Author: Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders (Workshop)
Other Authors: Stroud, Clare (rapporteur.), Keren, Noam I. (rapporteur.), Norris, Sheena M. Posey (rapporteur.)
Format: Electronic Conference Proceeding eBook
Language:Inglés
Published: Washington, DC : The National Academies Press, [2017]
Series:Online access: NCBI NCBI Bookshelf.
Online access: National Academy of Sciences National Academies Press.
Subjects:
Nervous system > Diseases > Congresses.
Nervous system > Diseases.
Nervous System Diseases
Clinical Trials as Topic
Système nerveux > Maladies > Congrès.
Système nerveux > Maladies.
MEDICAL > Pharmacology.
Nervous system > Diseases
Congress
proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Online Access:Texto completo
Table of Contents:
  • Introduction and overview
  • Drug development for nervous system disorders: overview of challenges adn potential opportunities
  • Case studies: therapeutic development for Parkinson's disease and schizophrenia in the absence of predictive animal models of disease
  • New modeling approaches for nervous system disorders
  • Private-sector thresholds for investment in neuroscience clinical trials
  • Ethical considerations
  • Regulatory perspectives
  • Appendix A: References
  • Appendix B: Workshop agenda
  • Appendix C: Registered attendees.

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