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|a UAMI
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| 245 |
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|a Frontiers in clinical drug research.
|n Volume 3,
|p Diabetes and obesity /
|c editor, Atta-ur-Rahman.
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| 260 |
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|a Sharjah :
|b Bentham Science Publishers,
|c 2016.
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| 300 |
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|a 1 online resource (257 pages)
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| 336 |
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|a text
|b txt
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|2 rdamedia
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|a Frontiers in Clinical Drug Research - Diabetes and Obesity
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|a Print version record.
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|a PREFACE ; List of Contributors ; Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope ; INTRODUCTION; The Discovery of Exendin-4; Fundamental Aspects of Exendin-4; Present Status of Exendin-4 for the Treatment of Type 2 Diabetes; INTERACTION OF EXENDIN-4 WITH GLP-1 RECEPTOR; GLP-1 Receptor and Its Dimerization; Exendin-4 Binding to GLP-1 Receptor; MODIFICATION OF EXENDIN-4 AND RELATED APPLICATIONS; Improved Stability and Binding Affinity; Improved Oral Bioavailability; Vitamin Conjugation; Low Molecular Weight Chitosan Conjugation.
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| 505 |
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|a Cholera Toxin B Subunit FusionExtended Half-life and Long Acting Preparations; Dimeric Exendin-4; Bile Acid Conjugation; Poly (Ethylene Glycol) Conjugation; Human Serum Albumin Conjugation; Albumin-Binding Domain Conjugation; Hyaluronate Conjugation; Mixed Strategies; CONCLUSION AND FUTURE PERSPECTIVES; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; The Growth Hormone/Insulin-like Growth Factor System in the Management of Diabetes and Obesity ; INTRODUCTION; Overview of the GH/IGF System; Metabolic Actions of the GH/IGF System ; THERAPEUTIC CONSIDERATIONS; Obesity.
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|a Severe Insulin ResistanceType 2 Diabetes; Type 1 Diabetes; CONCLUSION; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Insulin, Cardiovascular Function and Long-Term Diabetic Complications ; INTRODUCTION; The Role of Hyperglycemia; Insulin and Muscle Capillary Function; Muscle Sympathetic Nerve Activity; Insulin and Capillary Recruitment; NO, Nitric Oxide, Endothelium-derived Relaxing Factor; Insulin, Skeletal Muscle Blood Flow and Obesity; Kidney: Insulin and Albumin Excretion; Kidney: Albumin Excretion and Diabetic Nephropathy; Long-term Diabetic Complications; Drug Discovery Science.
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|a CONCLUSIONCONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Pharmacological Relevance of Novel Biomarkers Associated with Diabetes-mellitus Related Infertility ; 1. INTRODUCTION; 2. TESTICULAR PHYSIOLOGY AND ANATOMY; 2.1. Sertoli Cells: Morphology and Structure; 2.2. Spermatogenesis: A Brief Overview; 2.3. Regulation of Spermatogenesis; 2.3.1. Hormonal Control of Spermatogenesis; 3. TESTICULAR METABOLIC CO-OPERATION; 3.1. The Metabolism of Sertoli Cells; 3.2. The Metabolic Support of Developing Germ Cells.
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|a 3.3. The Metabolic Requirements of Spermatozoa: Considerations about Glucose Metabolism4. IMPACT OF DIABETIC STAGES IN MALE FERTILITY; 4.1. Glycemic Trajectories: From the High-risk State to the Established Diabetes Mellitus; 4.2. The Effects of Diabetes Mellitus in Male Fertility: A Clinical Perspective; 5. DIABETES MELLITUS AS A THREAT FOR TESTICULAR METABOLISM; 5.1. Testicular Oxidative Stress Induced by Progressive Diabetic Stages; 6. TESTICULAR METABOLIC CO-OPERATION AS POTENTIAL PHARMACOLOGIC TARGET TO COUNTERACT DIABETES MELLITUS -- ASSOCIATED SUBFERTILITY AND INFERTILITY.
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| 500 |
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|a 7. INSIGHTS IN THE EPIGENETIC OUTCOMES OF DIABETES MELLITUS ON MALE FERTILITY.
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| 590 |
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|a eBooks on EBSCOhost
|b EBSCO eBook Subscription Academic Collection - Worldwide
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| 590 |
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|a ProQuest Ebook Central
|b Ebook Central Academic Complete
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| 650 |
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0 |
|a Diabetes.
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| 650 |
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|a Diabetes
|x Treatment.
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| 650 |
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|a Obesity.
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| 650 |
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2 |
|a Obesity
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| 650 |
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6 |
|a Obésité.
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| 650 |
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|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
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| 650 |
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7 |
|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Diseases.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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| 650 |
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7 |
|a Diabetes
|2 fast
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| 650 |
|
7 |
|a Diabetes
|x Treatment
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| 650 |
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7 |
|a Obesity
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| 700 |
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|a Atta-ur-Rahman.
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|i has work:
|a Frontiers in Clinical Drug Research Volume 4 Diabetes and Obesity (Text)
|1 https://id.oclc.org/worldcat/entity/E39PCGrvHphwBbmjGvtMGxHHRX
|4 https://id.oclc.org/worldcat/ontology/hasWork
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|i Print version:
|a Atta-ur-Rahman.
|t Frontiers in Clinical Drug Research - Diabetes and Obesity volume 3.
|d Sharjah : Bentham Science Publishers, ©2016
|z 9781681082486
|
| 830 |
|
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|a Frontiers in Clinical Drug Research - Diabetes and Obesity.
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|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4768336
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