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|2 23
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|a UAMI
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| 245 |
0 |
0 |
|a Chemical ligation :
|b tools for biomolecule synthesis and modification /
|c edited by Luca D. D'Andrea, Alessandra Romanelli.
|
| 264 |
|
1 |
|a Hoboken, NJ :
|b John Wiley & Sons, Inc.,
|c 2017.
|
| 300 |
|
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|a 1 online resource
|
| 336 |
|
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|a text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a computer
|b n
|2 rdamedia
|
| 338 |
|
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|a online resource
|b nc
|2 rdacarrier
|
| 504 |
|
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|a Includes bibliographical references and index.
|
| 588 |
0 |
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|a Print version record and CIP data provided by publisher.
|
| 505 |
0 |
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|6 880-01
|a Cover; Title Page; Copyright; Contents; List of Figures; List of Plates; List of Contributors; Preface; Chapter 1 Introduction to Chemical Ligation Reactions; 1.1 Introduction; 1.1.1 Chemical Synthesis of Proteins: From the Stepwise Synthesis to the Chemical Ligation Approach; 1.1.2 Chemical Modification of Proteins: From Conventional Methods to Chemoselective Labeling by Chemical Ligation; 1.2 Chemical Ligation Chemistries; 1.3 Imine Ligations; 1.3.1 Oxime Ligation; 1.3.2 Hydrazone Ligation; 1.3.3 Pictet-Spengler Ligation; 1.3.4 Thiazolidine Ligation; 1.4 Serine/Threonine Ligation (STL).
|
| 505 |
8 |
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|a 2.3.2 SEAon/off Concept and the Design of a One-Pot Three Peptide Segment Assembly Process2.3.3 SEA on/off Concept and the Solid-Phase Synthesis of Proteins in the N-to-C Direction; 2.4 Chemical Synthesis of HGF/SF Subdomains for Deciphering the Functioning of HGF/SF-MET System; 2.5 Conclusion; References; Chapter 3 Development of Serine/Threonine Ligation and Its Applications; 3.1 Introduction; 3.1.1 Protein Synthesis by SPPS; 3.1.2 Native Chemical Ligation (and Extended Desulfurization); 3.1.3 KAHA Ligation; 3.2 Serine/Threonine Ligation (STL); 3.2.1 SAL Ester Preparation.
|
| 505 |
8 |
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|a 3.2.2 N-Terminal-Protecting Group for Successive C-to-N Ser/Thr Ligations3.2.3 Scope and Limitations; 3.3 Application of STL in Protein Synthesis; 3.3.1 Consecutive STL of Peptides/Proteins; 3.3.2 STL-Mediated Peptide Cyclization; 3.3.3 Thiol SAL Ester-Mediated Aminolysis in Peptide Cyclization; 3.3.4 A Fluorogenic Probe for Recognizing 5-OH-Lys Inspired by STL; 3.3.5 Expressed Protein Semisynthesis via Ser/Thr Ligation; 3.4 Conclusion and Outlook; References; Chapter 4 Synthesis of Proteins by Native Chemical Ligation-Desulfurization Strategies; 4.1 Introduction.
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| 505 |
8 |
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|a 4.2 Ligation-Desulfurization and Early Applications4.2.1 Metal-Free Desulfurization; 4.2.2 Ligation-Desulfurization toward the Synthesis of Proteins; 4.3 Beyond Native Chemical Ligation at Cysteine -- The Development of Thiolated Amino Acids and Their Application in Protein Synthesis; 4.3.1 Phenylalanine; 4.3.2 Valine; 4.3.3 Lysine; 4.3.4 Threonine; 4.3.5 Leucine; 4.3.6 Proline; 4.3.7 Glutamine; 4.3.8 Arginine; 4.3.9 Aspartic Acid; 4.3.10 Glutamic Acid; 4.3.11 Tryptophan; 4.3.12 GlcNAc-Asparagine; 4.3.13 Asparagine; 4.4 Ligation-Deselenization in the Chemical Synthesis of Proteins.
|
| 590 |
|
|
|a ProQuest Ebook Central
|b Ebook Central Academic Complete
|
| 650 |
|
0 |
|a Biosynthesis.
|
| 650 |
|
0 |
|a Peptides
|x Synthesis.
|
| 650 |
|
0 |
|a Proteins
|x Synthesis.
|
| 650 |
|
0 |
|a Bioorganic chemistry.
|
| 650 |
|
0 |
|a Chemistry, Organic.
|
| 650 |
|
6 |
|a Biosynthèse.
|
| 650 |
|
6 |
|a Peptides
|x Synthèse.
|
| 650 |
|
6 |
|a Protéines
|x Synthèse.
|
| 650 |
|
6 |
|a Chimie bio-organique.
|
| 650 |
|
6 |
|a Chimie organique.
|
| 650 |
|
7 |
|a organic chemistry.
|2 aat
|
| 650 |
|
7 |
|a MEDICAL
|x Physiology.
|2 bisacsh
|
| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Human Anatomy & Physiology.
|2 bisacsh
|
| 650 |
|
7 |
|a Bioorganic chemistry
|2 fast
|
| 650 |
|
7 |
|a Biosynthesis
|2 fast
|
| 650 |
|
7 |
|a Chemistry, Organic
|2 fast
|
| 650 |
|
7 |
|a Peptides
|x Synthesis
|2 fast
|
| 650 |
|
7 |
|a Proteins
|x Synthesis
|2 fast
|
| 700 |
1 |
|
|a D'Andrea, Luca D.,
|e editor.
|
| 700 |
1 |
|
|a Romanelli, Alessandra,
|e editor.
|
| 758 |
|
|
|i has work:
|a Chemical ligation (Text)
|1 https://id.oclc.org/worldcat/entity/E39PD3y7RvJyf4CVFYCQRPfxym
|4 https://id.oclc.org/worldcat/ontology/hasWork
|
| 776 |
0 |
8 |
|i Print version:
|t Chemical ligation.
|d Hoboken, NJ : John Wiley & Sons, Inc., 2017
|z 9781119044109
|w (DLC) 2016052028
|
| 856 |
4 |
0 |
|u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4826761
|z Texto completo
|
| 880 |
8 |
|
|6 505-01/(S
|a 1.5 Thioether Ligation1.6 Thioester Ligation; 1.6.1 Native Chemical Ligation (NCL); 1.6.2 Expressed Protein Ligation (EPL); 1.6.3 Thioacid-Mediated Ligation Strategies; 1.7 α-Ketoacid-Hydroxylamine (KAHA) Ligation; 1.7.1 Acyltrifluoroborates and Hydroxylamines Ligation; 1.8 Staudinger Ligation; 1.9 Azide-Alkyne Cycloaddition; 1.10 Diels-Alder Ligation; References; Chapter 2 Protein Chemical Synthesis by SEA Ligation; 2.1 Introduction; 2.2 Essential Chemical Properties of SEA Group; 2.3 Protein Total Synthesis Using SEA Chemistry -- SEAon/off Concept; 2.3.1 Synthesis of SEAoff Peptide Segments.
|
| 938 |
|
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|a EBL - Ebook Library
|b EBLB
|n EBL4826761
|
| 938 |
|
|
|a EBSCOhost
|b EBSC
|n 1487833
|
| 938 |
|
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|a ProQuest MyiLibrary Digital eBook Collection
|b IDEB
|n cis36843304
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|a YBP Library Services
|b YANK
|n 13813062
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|a Askews and Holts Library Services
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