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Osteoimmunology : interactions of the immune and skeletal systems /
Of Section II: Multiple Cell Types Promote Bone Formation During the Remodeling Process -- What is the target cell of osteoclast-derived factors that may promote bone formation? -- How do osteocytes contribute to coupling? -- Promotion of bone formation in the BMU during the reversal phase -- The in...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2015.
|
| Edición: | Second edition. |
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 001 | EBOOKCENTRAL_ocn932060757 | ||
| 003 | OCoLC | ||
| 005 | 20240329122006.0 | ||
| 006 | m o d | ||
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| 008 | 150706s2015 ne ob 001 0 eng d | ||
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| 029 | 1 | |a UKMGB |b 017445881 | |
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| 050 | 4 | |a QP88.2 ǂb O884 2016eb | |
| 082 | 0 | 4 | |a 616.7079 |2 23 |
| 049 | |a UAMI | ||
| 245 | 0 | 0 | |a Osteoimmunology : |b interactions of the immune and skeletal systems / |c edited by Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Hiroshi Takayanagi and Georg Schett. |
| 250 | |a Second edition. | ||
| 264 | 1 | |a Amsterdam : |b Academic Press, |c 2015. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a CIP data; item not viewed. | |
| 505 | 0 | |a Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Foreword -- Preface -- Chapter 1 -- Overview: The Developing Field of Osteoimmunology -- References -- Chapter 2 -- The Origins of the Osteoclast -- First descriptions of the osteoclast -- Early controversies: are osteoclasts capable of bone resorption? -- Early controversies: hematopoietic or mesenchymal origin of the osteoclast? -- Osteoclast: a hematopoietic cell -- Osteoclasts: cells of the myeloid lineage -- Advancing the field: culturing osteoclasts in vitro -- Identification of RANKL and OPG -- Defining osteoclast precursors within myeloid cell development -- Heterogeneity among osteoclasts -- Origins of the osteoclast through the lens of evolution -- Osteoclast-Like Activity in Invertebrates -- Osteoclasts in Fish -- Conclusions -- Acknowledgments -- References -- Chapter 3 -- Trafficking of Osteoclast Precursors -- Introduction -- A century-long search for the identity of osteoclast precursors -- Intravital two-photon imaging of bone tissues -- Osteoclast precursors are motile and circulate throughout the body -- Guidance cues sensed by osteoclast precursors in bone marrow -- S1P-dependent migratory control of osteoclast precursors -- Differences between osteoclast precursor and mature osteoclast migration mechanisms -- Control of osteoclast migration and function by Rho GTPases -- Role of integrins in osteoclast precursor migration -- Control of osteoclast precursor differentiation by GPCR-mediated inhibition of cell migration -- Unanswered questions in osteoclast precursor trafficking and differentiation -- References -- Chapter 4 -- Osteoclast Biology: Regulation of Formation and Function -- Introduction -- RANKL and RANK: an osteoclastogenic cytokine and its receptor -- TRAF6: the multifunctional signaling molecule activated by RANK. | |
| 505 | 8 | |a What happens downstream of TRAF6? -- The role of NF-kB in osteoclast differentiation -- The critical role of AP-1 transcription factors -- MAPKs activated by RANKL -- NFATc1 is a master transcription factor of osteoclast differentiation -- Autoamplification of NFATc1 and its epigenetic regulation -- Inhibition of NFATc1 induction -- Transcriptional control governed by NFATc1 -- Costimulatory receptor signals for RANK: FcRg and DAP12 -- The ligands for the costimulatory receptors -- Importance of ITAM costimulatory signals in humans: Nasu-Hakola disease -- Additional costimulatory signals involved in osteoclastogenesis -- Receptors signaling through DAP12 -- The inhibitory signals for costimulatory signals -- Src family kinases: activation of ITAM signaling -- Syk kinase: downstream of DAP12/FcRg? -- PLCg2: enzyme and adaptor molecule -- Tec kinases: integrating RANK and ITAM signaling -- Negative regulatory role of DAP12 -- M-CSF and c-Fms: a road to proliferation and survival -- M-CSF signaling -- Erk, PI3K, and c-Fos signaling -- The osteoclast's job: bone resorption -- Osteoclast cytoskeleton: the podosomes and the sealing zone -- Osteoclast cytoskeleton: the microtubules and the sealing zone -- Osteoclast functional structure: the ruffled border -- Osteoclast and bone matrix: role of ÜvÝ3 integrin -- Integrin-associated proteins -- M-CSF and the osteoclast cytoskeleton -- Coupling factors released in osteoclastic bone resorption -- Stimulation of bone formation by clastokines -- Inhibition of bone formation by clastokines -- Coupling by cell-cell interaction between osteoclasts and osteoblasts -- Conclusions -- References -- Chapter 5 -- Osteoimmunology and the Osteoblast -- Advantages of immune-osteoblast interaction -- Immune-osteoblast interaction in fracture repair -- Immune Cells Set the Order and Tempo of Fracture Repair. | |
| 505 | 8 | |a Dual role for TNF-Ü -- TNF is an inhibitor of Wnt signaling -- Coupling of skeletal homeostasis with innate and acquired immunity -- Normal Bone Remodeling -- Osteoblast support of hematopoiesis -- Osteoblast support of B cell differentiation -- Osteoblasts support hematopoietic stem cells -- Conclusions -- References -- Chapter 6 -- The Variety of Osteocyte Function -- Introduction -- The osteocyte network -- New tools to study osteocyte function -- Osteocytes and bone remodeling -- Osteocytes and mineral homeostasis -- Osteocytes as mechanosensors -- Osteocytes and hematopoiesis -- Conclusions -- References -- Chapter 7 -- Bone Marrow Hematopoietic Niches -- Introduction -- Hematopoiesis occurs within the bone marrow and is closely linked to skeletal development -- A role for the osteoblast lineage in supporting hematopoietic stem cells -- A perivascular niche for HSCs involves mesenchymal progenitors -- Signaling pathways implicated in microenvironment-HSC communication -- CXCL12/CXCR4 -- SCF -- Angiopoietin-1/Tie2 -- Thrombopoietin/Mpl -- Osteopontin -- Calcium-Sensing Receptor -- N-Cadherin -- Parathyroid Hormone Receptor Signaling -- Notch Signaling -- Wnt Signaling -- Prostaglandin E2 -- TGFÝ1 -- Perivascular osteoblast precursors support hematopoiesis -- Other components of the hematopoietic niche -- Macrophages -- Endothelial Cells -- Sympathetic Neurons -- Adipocytes -- Clinical implications -- HSC Engraftment After Transplantation -- Microenvironment and Disease -- Effect of Aging-Related Bone Loss on Hematopoiesis -- The bone marrow HSC microenvironment is complex -- References -- Chapter 8 -- RANK and RANKL of Bones, T Cells, and the Mammary Glands -- RANK and RANKL in bone -- Downstream signaling of RANK/RANKL -- Rank/Rankl mutations in human patients -- Osteoimmunology -- RANK and RANKL in the organogenesis of the immune system. | |
| 505 | 8 | |a Immunotolerance -- RANK/RANKL and metastases -- RANK/RANKL and the mammary gland -- RANK and RANKL and their function in mammary stem cell biology -- Breast cancer -- Is there even more? -- Denosumab, a rational treatment for bone loss -- Conclusions -- References -- Chapter 9 -- The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells -- Receptor activator of nuclear factor-kB ligand (RANKL), receptor activator of nuclear factor-kB (RANK) and osteoprotegerin ... -- Colony-stimulating factor-1 -- Additional colony stimulating factors -- Interleukin-1 -- Tumor necrosis factor -- Additional TNF superfamily members -- Fas-Ligand -- TNF-Related Apoptosis Inducing Ligand (TRAIL) -- CD40-ligand -- Interleukin-6 -- Additional interleukin-6 family members -- Interleukin-11 -- Leukemia Inhibitory Factor -- Oncostatin M -- Interleukin-7 -- Interleukin-8 and other chemokines -- Interleukin-8 -- CCL2 -- CCL3 -- CCL9 -- CXCL12 and CXCR4 -- CX3CR1 -- CCR1 -- CCR2 -- Interleukin-10 -- Interleukin 12 -- Interleukin 15 -- Interleukin 17, Interleukin 23, and Interleukin 27 -- Interleukin 18 and interleukin 33 -- Interferons -- Additional cytokine -- Conclusions -- References -- Chapter 10 -- Coupling: The Influences of Immune and Bone Cells -- Introduction: bone remodeling and the concept of coupling -- Modeling and remodeling in anabolic therapy for the skeleton -- Osteoclast-derived factors that promote osteoblast differentiation -- Matrix-Derived Signals Released During Resorption -- Factors Secreted by the Osteoclast That Promote Bone Formation -- Do Macrophages Also Stimulate Bone Formation in the BMU? -- Other Contributions of Macrophages to Bone Formation in Remodeling -- Proteins Expressed on the Osteoclast Cell Membrane That Stimulate Osteoblast Differentiation. | |
| 520 | |a Of Section II: Multiple Cell Types Promote Bone Formation During the Remodeling Process -- What is the target cell of osteoclast-derived factors that may promote bone formation? -- How do osteocytes contribute to coupling? -- Promotion of bone formation in the BMU during the reversal phase -- The influences of T and B lymphocytes on the coupling process -- Signals between the bone surface and the vasculature -- Isolation of the remodeling site by the bone remodeling canopy -- Conclusions -- References -- Chapter 11 - The Role of the Immune System in the Development of Osteoporosis and Fracture Risk -- Introduction -- Connections between bone and the immune system -- Bone remodeling -- Periarticular bone structure and bone loss in inflammatory arthritis -- Bone involvement in rheumatic diseases -- Bone Changes in Rheumatic Diseases -- Bone Erosions -- Bone Marrow Edema (BME) -- Local Peri-Inflammatory Bone Changes -- Generalized Bone Changes -- Fracture Healing -- Methods for quantifying changes in bone in inflammatory rheumatic diseases -- CR -- High-resolution CR -- Radiogrammetry and DXR -- Photonabsorptiometry -- Magnetic resonance imaging (MRI) -- Quantitative ultrasound (QUS) of the bone -- Musculoskeletal ultrasound (MSUS) -- Quantitative computed tomography (QCT) -- High resolution peripheral quantitative computed tomography (HRpQCT) -- Bone and inflammation markers -- Clinical risk factors for low BMD, falls, and fractures -- From fracture risk evaluation to fracture prevention: a 5-step plan -- Case Finding -- Risk Evaluation -- Clinical Risk Factors -- Measurements and Imaging Tools -- Biomarkers -- Risk of falls in RA -- Differential diagnosis -- Fracture prevention in inflammatory joint diseases -- General Measures -- Calcium and Vitamin D -- Treatment of Glucocorticoid Osteoporosis. | ||
| 504 | |a Includes bibliographical references at the end of each chapters and index. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Musculoskeletal system |x Immunology. | |
| 650 | 6 | |a Appareil locomoteur |x Immunologie. | |
| 700 | 1 | |a Lorenzo, Joseph, |e editor. | |
| 700 | 1 | |a Horowitz, Mark, |e editor. | |
| 700 | 1 | |a Choi, Yongwon, |e editor. | |
| 700 | 1 | |a Takayanagi, Hiroshi, |e editor. | |
| 700 | 1 | |a Schett, Georg, |e editor. | |
| 758 | |i has work: |a Osteoimmunology (Text) |1 https://id.oclc.org/worldcat/entity/E39PCYqxVt3TtVbJcDhbKtJrTw |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version |z 9780128005712 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4003868 |z Texto completo |
| 938 | |a EBL - Ebook Library |b EBLB |n EBL4003868 | ||
| 994 | |a 92 |b IZTAP | ||