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Virus as populations : composition, complexity, dynamics, and biological implications /
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Academic Press,
2015.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title page; Table of Contents; Copyright; Foreword; Acknowledgments; Chapter 1: Introduction to Virus Origins and Their Role in Biological Evolution; Abstract; 1.1 Considerations on Biological Diversity; 1.2 Some Questions of Current Virology and the Scope of This Book; 1.3 The Staggering Ubiquity and Diversity of Viruses: Limited Morphotypes; 1.4 Origin of Life: A Brief Historical Account and Current Views; 1.5 Theories of the Origins of Viruses; 1.6 Being Alive Versus Being Part of Life; 1.7 Role of Viruses in the Evolution of the Biosphere; 1.8 Virus and Disease.
- 1.9 Overview and Concluding RemarksChapter 2: Molecular Basis of Genetic Variation of Viruses: Error-Prone Replication; Abstract; 2.1 Universal Need of Genetic Variation; 2.2 Molecular Basis of Mutation; 2.3 Types and Effects of Mutations; 2.4 Inferences on Evolution Drawn from Mutation Types; 2.5 Mutation Rates and Frequencies for DNA and RNA Genomes; 2.6 Evolutionary Origins, Evolvability, and Consequences of High Mutation Rates: Fidelity Mutants; 2.7 Hypermutagenesis and Its Application to Generate Variation: APOBEC and ADAR Activities.
- 2.8 Error-Prone Replication and Maintenance of Genetic Information: Instability of Laboratory Viral Constructs2.9 Recombination in DNA and RNA Viruses; 2.10 Genome Segment Reassortment; 2.11 Transition Toward Viral Genome Segmentation: Implications for General Evolution; 2.12 Mutation, Recombination, and Reassortment as Individual and Combined Evolutionary Forces; 2.13 Overview and Concluding Remarks; Chapter 3: Darwinian Principles Acting on Highly Mutable Viruses; Abstract; 3.1 Theoretical Frameworks to Approach Virus Evolution; 3.2 Genetic Variation, Competition, and Selection.
- 3.3 Mutant Distributions During DNA and RNA Virus Infections3.4 Positive Versus Negative Selection: Two Sides of the Same Coin; 3.5 Selection and Random Drift; 3.6 Viral Quasispecies; 3.7 Sequence Space and State Transitions; 3.8 Modulating Effects of Mutant Spectra: Complementation and Interference: An Ensemble as the Unit of Selection; 3.9 Viral Populations in Connection with Biological Complexity; 3.10 Overview and Concluding Remarks; Chapter 4: Interaction of Virus Populations with Their Hosts; Abstract; 4.1 Contrasting Viral and Host Population Numbers.
- 4.2 Types of Constraints and Evolutionary Trade-Offs in Virus-Host Interactions4.3 Codon Usage as a Selective Constraint: Virus Attenuation Through Codon and Codon-pair Deoptimization; 4.4 Modifications of Host Cell Tropism and Host Range; 4.5 Trait Coevolution: Mutual Influences Between Antigenic Variation and Tropism Change; 4.6 Escape from Antibody and Cytotoxic T Cell Responses in Viral Persistence: Fitness Cost; 4.7 Antigenic Variation in the Absence of Immune Selection; 4.8 Constraints as a Demand on Mutation Rate Levels.