From biosynthesis to total synthesis : strategies and tactics for natural products /

Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total s...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Zografos, Alexandros L. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Hoboken, New Jersey : John Wiley & Sons, Inc., [2016]
Temas:
Organic compounds > Synthesis.
Biosynthesis.
Composés organiques > Synthèse.
Biosynthèse.
SCIENCE > Life Sciences > Biochemistry.
Biosynthesis
Organic compounds > Synthesis
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Title Page
  • Copyright Page
  • Contents
  • List of Contributors
  • Preface
  • Chapter 1 From Biosyntheses to Total Syntheses: An Introduction
  • 1.1 FROM PRIMARY TO SECONDARY METABOLISM: THE KEY BUILDING BLOCKS
  • 1.1.1 Definitions
  • 1.1.2 Energy Supply and Carbon Storing at the Early Stage of Metabolisms
  • 1.1.3 Glucose as a Starting Material Toward Key Building Blocks of the Secondary Metabolism
  • 1.1.4 Reactions Involved in the Construction of Secondary Metabolites
  • 1.1.5 Secondary Metabolisms.
  • 1.2 FROM BIOSYNTHESIS TO TOTAL SYNTHESIS: STRATEGIES TOWARD THE NATURAL PRODUCT CHEMICAL SPACE
  • 1.2.1 The Chemical Space of Natural Products
  • 1.2.2 The Biosynthetic Pathways as an Inspiration for Synthetic Challenges
  • 1.2.3 The Science of Total Synthesis
  • 1.2.4 Conclusion: A Journey in the Future of Total Synthesis
  • REFERENCES
  • SECTION I ACETATE BIOSYNTHETIC PATHWAY
  • Chapter 2 Polyketides
  • 2.1 POLYKETIDE BIOSYNTHESIS
  • 2.1.1 Introduction
  • 2.1.2 Assembly of Acetate/Malonate-Derived Metabolites
  • 2.1.3 Classification of Polyketide Biosynthetic Machineries
  • 2.1.4 Conclusion.
  • Chapter 3 FATTY ACIDS AND THEIR DERIVATIVES
  • 3.1 INTRODUCTION
  • 3.2 BIOSYNTHESIS
  • 3.2.1 Fatty Acids and Lipids
  • 3.2.2 Polyunsaturated Fatty Acids
  • 3.2.3 Mediated Oxidations of (S} (B-3 and (S} (B-6 Polyunsaturated Fatty Acids
  • 3.3 SYNTHESIS OF (S} (B-3 AND (S} (B-6 ALL-Z POLYUNSATURATED FATTY ACIDS
  • 3.3.1 Synthesis of Polyunsaturated Fatty Acids by the Wittig Reaction or by the Polyyne Semihydrogenation
  • 3.3.2 Synthesis of Polyunsaturated Fatty Acids via Cross Coupling Reactions
  • 3.4 APPLICATIONS IN TOTAL SYNTHESIS OF POLYUNSATURATED FATTY ACIDS
  • 3.4.1 Palladium-Catalyzed Cross Coupling Reactions.
  • 3.4.2 Biomimetic Transformations of Polyunsaturated Fatty Acids
  • 3.4.3 Landmark Total Syntheses
  • 3.4.4 Synthesis of Leukotriene B5
  • 3.5 CONCLUSION
  • ACKNOWLEDGMENTS
  • References
  • Chapter 4 Polyethers
  • 4.1 INTRODUCTION
  • 4.2 BIOSYNTHESIS
  • 4.2.1 Ionophore Antibiotics
  • 4.2.2 Marine Ladder Toxins
  • 4.2.3 Annonaceous Acetogenins and Terpene Polyethers
  • 4.3 EPOXIDE REACTIVITY AND STEREOSELECTIVE SYNTHESIS
  • 4.3.1 Regiocontrol in Epoxide-Opening Reactions
  • 4.3.2 Stereoselective Epoxide Synthesis
  • 4.4 APPLICATIONS TO TOTAL SYNTHESIS
  • 4.4.1 Acid-Mediated Transformations.

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