(NAS Colloquium) Self-Perpetuating Structural States in Biology, Disease, and Genetics.

Bibliographic Details
Call Number:Libro Electrónico
Main Author: Sciences, Proceedings of the National Academy of
Format: Electronic eBook
Language:Inglés
Published: Washington : National Academies Press, 2002.
Series:Online access: NCBI NCBI Bookshelf.
Subjects:
Biology > Congresses.
Proteins > Conformation > Congresses.
Biologie > Congrès.
Protéines > Conformation > Congrès.
Biology
Proteins > Conformation
Conference papers and proceedings
Online Access:Texto completo
Table of Contents:
  • Self-Perpetuating Structural States in Biology, Disease, and Genetics
  • Copyright
  • Contents
  • Colloquium Self-perpetuating structural states in biology, disease, and genetics
  • Colloquium Transmission of prions
  • “NATURALâ€? TRANSMISSION OF PRIONS
  • IATROGENIC TRANSMISSION OF PRIONS
  • EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS
  • CONCLUDING REMARKS
  • Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Interactions among prions and prion “strainsâ€? in yeastMATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease byâ€?
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Chaperoning brain degeneration
  • MATERIALS AND METHODS
  • A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE
  • THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY
  • CHAPERONE SUPPRESSION OF Î?-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASEENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE
  • DISCUSSION
  • Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
  • MECHANISM OF POLYQ AGGREGATION
  • RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY
  • TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION
  • ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY
  • ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITYPERSPECTIVES
  • Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • CONCLUSION
  • Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity
  • METHODS
  • RESULTS AND DISCUSSION
  • Colloquium The insulation of genes from external enhancers and silencing chromatin
  • AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT
  • INSULATORS AS BARRIERSCONCLUSION
  • Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prionâ€?
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION
  • Colloquium Heritable chromatin structure: Mapping “memoryâ€? in histones H3 and H4
  • MATERIALS AND METHODS
  • RESULTS
  • DISCUSSION

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