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Pharmaceutical blending and mixing /
Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Chichester, Sussex, UK ; Hoboken, NJ :
Wiley,
2015.
|
| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 245 | 0 | 0 | |a Pharmaceutical blending and mixing / |c edited by P.J. Cullen, Rodolfo J. Romañach, Nicolas Abatzoglou, Chris Rielly. |
| 264 | 1 | |a Chichester, Sussex, UK ; |a Hoboken, NJ : |b Wiley, |c 2015. | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 588 | 0 | |a Print version record and CIP data provided by publisher. | |
| 505 | 0 | |a Title Page; Copyright Page; Contents; Contributor List; Preface; Part I Fundamentals of Mixing; Chapter 1 Mixing Theory; 1.1 Introduction; 1.2 Describing Mixtures; 1.3 Scale of Scrutiny; 1.4 Quantifying Mixedness for Coarse and Fine-Grained Mixtures; 1.4.1 Coarse and Fine-Grained Mixtures; 1.4.2 Scale and Intensity of Segregation; 1.5 Determining the End-Point of Mixing: Comparison of Mixing Indices; 1.6 Continuous Flow Mixers; 1.6.1 Idealized Mixing Patterns; 1.6.2 Residence Time Distributions; 1.6.3 Back-Mixing and Filtering of Disturbances Using a CSTR; References. | |
| 505 | 8 | |a Chapter 2 Turbulent Mixing Fundamentals2.1 Introduction; 2.2 The Velocity Field and Turbulence; 2.3 Circulation and Macro-Mixing; 2.4 Fully Turbulent Limits and the Scaling of Turbulence; 2.5 The Spectrum of Turbulent Length Scales, Injection of a Scalar (Either Reagent or Additive) and the Macro-, Meso- and Micro-Scales of Mixing; 2.6 Turbulence and Mixing of Solids, Liquids, and Gases; 2.7 Specifying Mixing Requirements for a Process; 2.8 Conclusions; Notation; Roman Characters; Greek Characters; References; Chapter 3 Laminar Mixing Fundamentals; 3.1 Laminar Flows. | |
| 505 | 8 | |a 3.2 Mixing in Laminar Flows3.2.1 Chaos and Laminar Chaotic Mixing; 3.2.2 Granular Chaotic Mixing; 3.3 Recent Advances; References; Chapter 4 Sampling and Determination of Adequacy of Mixing; 4.1 Introduction, Process Understanding, and Regulations; 4.2 Theory of Sampling; 4.3 Sampling of Pharmaceutical Powder Blends; 4.4 Stratified Sampling Approach; 4.5 Testing; 4.6 Process Knowledge/Process Analytical Technology; 4.7 Real Time Spectroscopic Monitoring of Powder Blending; 4.8 Looking Forward, Recommendations; 4.9 Conclusion; 4.10 Acknowledgments; References; Part II Applications. | |
| 505 | 8 | |a Chapter 5 Particles and Blending5.1 Introduction; 5.2 Particle Geometry; 5.2.1 Particle Size and Size Distribution; 5.2.2 Particle Shape and Shape Distribution; 5.3 Particle Interactions; 5.3.1 van der Waals Forces; 5.3.2 Electrostatic Forces; 5.3.3 Adsorbed Liquid Layers and Liquid Bridges; 5.3.4 Solid Bridges; 5.3.5 Use of AFM to Measure Interparticle Forces; 5.3.6 Interparticle Friction; 5.4 Empirical Investigations of Particles and Blending; 5.4.1 Blending of Powders; 5.4.2 Impact of Particle Geometry on Blending; 5.4.3 Impact of Interparticle Forces on Blending. | |
| 505 | 8 | |a 5.4.4 Impact of Blender Conditions on Blending5.5 Simulation Techniques; 5.5.1 Full Physics Models Using Discrete Element Modeling; 5.5.2 Continuum Models; 5.5.3 Cellular Automata; References; Chapter 6 Continuous Powder Mixing; 6.1 Introduction; 6.2 Overview; 6.3 Theoretical Characterization; 6.3.1 Residence Time Distribution (RTD) Modeling; 6.3.2 Variance Reduction Ratio; 6.4 Experimental Characterization; 6.4.1 Hold-Up; 6.4.2 Residence Time Distribution (RTD) Measurements; 6.4.3 Mean Strain; 6.5 Continuous Mixing Efficiency; 6.5.1 Variance Reduction Ratio; 6.5.2 Blend Homogeneity. | |
| 520 | |a Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering. | ||
| 590 | |a ProQuest Ebook Central |b Ebook Central Academic Complete | ||
| 650 | 0 | |a Pharmaceutical technology. | |
| 650 | 0 | |a Drug factories. | |
| 650 | 0 | |a Pharmaceutical industry. | |
| 650 | 2 | |a Drug Compounding |x methods | |
| 650 | 2 | |a Drug Compounding |x instrumentation | |
| 650 | 2 | |a Technology, Pharmaceutical | |
| 650 | 2 | |a Drug Industry | |
| 650 | 6 | |a Techniques pharmaceutiques. | |
| 650 | 6 | |a Laboratoires pharmaceutiques. | |
| 650 | 6 | |a Industrie pharmaceutique. | |
| 650 | 7 | |a TECHNOLOGY & ENGINEERING |x Chemical & Biochemical. |2 bisacsh | |
| 650 | 7 | |a Drug factories |2 fast | |
| 650 | 7 | |a Pharmaceutical industry |2 fast | |
| 650 | 7 | |a Pharmaceutical technology |2 fast | |
| 700 | 1 | |a Cullen, P. J. |q (Patrick J.), |e editor. | |
| 700 | 1 | |a Romañach, Rodolfo J., |e editor. | |
| 700 | 1 | |a Abatzoglou, Nicolas, |e editor. | |
| 700 | 1 | |a Rielly, C. D., |e editor. | |
| 758 | |i has work: |a Pharmaceutical blending and mixing (Text) |1 https://id.oclc.org/worldcat/entity/E39PCH6bdTV3xPmPDhjj37v8RX |4 https://id.oclc.org/worldcat/ontology/hasWork | ||
| 776 | 0 | 8 | |i Print version: |t Pharmaceutical blending and mixing. |d Chichester, United Kingdom : John Wiley & Sons, Ltd, 2015 |z 9780470710555 |w (DLC) 2015015496 |
| 856 | 4 | 0 | |u https://ebookcentral.uam.elogim.com/lib/uam-ebooks/detail.action?docID=4037527 |z Texto completo |
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