Proteomics : targeted technology, innovations and applications /

Targeted proteomics is a technology for detecting proteins of interest with high sensitivity, quantitative accuracy, and reproducibility. The analysis of a pre-defined group of proteins provides precise, quantitative, and sensitive data to scientists and clinicians and can provide information on a s...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Fuentes, Manuel (Editor ), LaBaer, Joshua (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Norfolk, England : Caister Academic Press, 2014.
Temas:
Proteomics.
Proteins > Structure.
Protein binding.
Gene expression.
Post-translational modification.
Proteomics
Protein Binding
Gene Expression
Protéomique.
Protéines > Structure.
Protéines > Fixation.
Expression génique.
Protéines > Modification post-traductionnelle.
SCIENCE > Life Sciences > Biochemistry.
Gene expression
Post-translational modification
Protein binding
Proteins > Structure
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Contributors; Current books of interest; Preface; 1: Serum Proteomics for Studying Disease Pathogenesis and Identification of Disease Biomarkers; Introduction; Challenges of serum proteome analysis; Proteomic techniques in serum profiling; Applications; Conclusion; 2: Serum Profiling by Targeted Proteomics for Biomarker Discovery; Biomarker discovery; Targeted proteomics; Serum profiling by targeted proteomics; Conclusions; 3: Targeted Proteomics: Applications in the Study of Liver Disorders; The liver; Shotgun proteomics and liver disorders.
  • MS-based targeted proteomics: selected reaction monitoring for protein detection and quantitationProtein regulation: targeted analysis of post-translational modifications based on enrichment procedures; Concluding remarks and future perspectives; 4: Targeted Proteomics for Chronic Lymphocytic Leukaemia; Introduction; Epidemiology and incidence; Clinical presentation; Monoclonal B lymphocytosis (MBL); Genetic and epigenetic analysis of CLL; Proteomics profiles in B-cell malignancies; Proteome analysis of B-cell maturation; Quantitative proteomics.
  • 'Shot gun' proteomic studies on B-cell malignanciesConclusions and future directions; 5: Protein Microarrays: A Versatile Tool for Scientific Discovery; Introduction; Basic research applications; Clinical research applications; Data analysis and bioinformatics; Outlook and perspective; 6: Bioinformatics Challenges in Targeted Proteomics; Introduction; Experimental design; Data acquisition and data processing; Noise reduction and normalization; Data interpretation.
  • 7: Standardized Formats, Report Information Guidelines, Mass Spectrometry-based Repositories and Application Programming Interfaces for Implementing Data Standards in ProteomicsBackground: HUPO-PSI; Standardization pillars: MIAPE guidelines, XML-based standard formats and controlled vocabularies; Proteomics repositories and databases; Application Programming Interfaces (APIs) for the integration of data standards into laboratory pipelines; Bioinformatics tools for creating and managing proteomics data standards; Data analysis and reporting tools; Conclusions.
  • 8: Clinical Protein Science and Targeted Mass Spectrometric Assays
  • New Frontiers in Disease Link and BiobankingThe unmet needs and progresses in modern healthcare; Building new medical frontiers in modern society; Impact to society of personalized medicines; Biobanking; Protein biomarkers and targeted analysis; Prostate cancer protein biomarker analysis; Conclusions; Index.

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