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Separation of Enantiomers.
In one handy volume this handbook summarizes the most common synthetic methods for the separation of racemic mixtures, allowing an easy comparison of the different strategies described in the literature. Alongside classical methods, the authors also consider kinetic resolutions, dynamic kinetic reso...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Wiley-VCH,
2014.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title Page; Related Titles; Copyright; List of Contributors; Chapter 1: Introduction: A Survey of How and Why to Separate Enantiomers; 1.1 Classical Methods; 1.2 Kinetic Resolution ('KR'); 1.3 Dynamic Kinetic Resolution ('DKR'); 1.4 Divergent Reactions of a Racemic Mixture ('DRRM'); 1.5 Other Methods; Acknowledgments; References; Chapter 2: Stoichiometric Kinetic Resolution Reactions; 2.1 Introduction; 2.2 Kinetic Treatment; 2.3 Chiral Reagents and Racemic Substrates; 2.4 Enantiodivergent Formation of Chiral Product; 2.5 Enantioconvergent Reactions; 2.6 Diastereomer Kinetic Resolution.
- 2.7 Some Applications of Kinetic Resolution2.8 Conclusion; References; Chapter 3: Catalytic Kinetic Resolution; 3.1 Introduction; 3.2 Kinetic Resolution of Alcohols; 3.3 Kinetic Resolution of Epoxides; 3.4 Kinetic Resolution of Amines; 3.5 Kinetic Resolution of Alkenes; 3.6 Kinetic Resolution of Carbonyl Derivatives; 3.7 Kinetic Resolution of Sulfur Compounds; 3.8 Kinetic Resolution of Ferrocenes; 3.9 Conclusions; Abbreviations; References; Chapter 4: Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions; 4.1 Introduction.
- 4.2 Kinetic Resolutions Using Hydrolytic Enzymes4.3 Dynamic Kinetic Resolution; 4.4 Deracemization; 4.5 Enantioconvergent Reactions; 4.6 Conclusions; References; Chapter 5: Dynamic Kinetic Resolution (DKR); 5.1 Introduction; 5.2 Definition and Classification; 5.3 Dynamic Kinetic Resolution (DKR); 5.4 Mathematical Expression; 5.5 DKR-Related Methods; 5.6 Concluding Remarks; References; Chapter 6: Enantiodivergent Reactions: Divergent Reactions on a Racemic Mixture and Parallel Kinetic Resolution; 6.1 Introduction: The Conceptual Basis for Kinetic Resolution and Enantiodivergent Reactions.
- 6.2 Divergent RRM Using a Single Chiral Reagent: Ketone Reduction6.3 Divergent RRM under Oxidative Conditions; 6.4 Organometallic Reagents and Regiodivergent RRM; 6.5 Regiodivergent RRM in Selective Reactions of Difunctional Substrates; 6.6 Divergent RRM Using Two Chiral Reagents: Parallel Kinetic Resolution (PKR); 6.7 Conclusion; Acknowledgement; References; Chapter 7: Rare, Neglected and Potential Synthetic Methods for the Separation of Enantiomers; 7.1 Resolution through the Selfish Growth of Polymers: Stereoselective Polymerization; 7.2 Resolution through Photochemical Methods.
- 7.3 Combinations of Crystallization and Racemization7.4 Destruction Then Recreation of Stereocentres: Enantioselective Protonations; 7.5 Dynamic Combinatorial Chemistry; 7.6 Asymmetric Autocatalysis; 7.7 Miscellaneous; 7.8 Concluding Remarks; Acknowledgements; References; Index; End User License Agreement.