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Stem Cell Repair and Regeneration - Volume 3.

Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. The third book in the Stem Cell Repair and Regeneration series offers contributions from numerous areas bridging medicine and the life sciences. Significant research activities in the tissue engi...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor principal: Habib, Nagy A.
Otros Autores: Gordon, M. Y. (Myrtle Y.), Dimarakis, Ioannis
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore : World Scientific Publishing Company, 2008.
Temas:
Acceso en línea:Texto completo

MARC

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245 1 0 |a Stem Cell Repair and Regeneration - Volume 3. 
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520 |a Stem cells have generated considerable interest recently in the scientific, clinical, and public arenas. The third book in the Stem Cell Repair and Regeneration series offers contributions from numerous areas bridging medicine and the life sciences. Significant research activities in the tissue engineering or regenerative medicine (the term recently used) field started in the 1970s, and there is currently great excitement over the possibility of replacing damaged body parts through regenerative medicine. Potential strategies to replace, repair and restore the function of damaged tissues or org. 
505 0 |a Contributors; Preface; Chapter 1. The Biology of Human Mesenchymal Stem Cells Claire Westwood and Mark O. Clements; Introduction; Historical Perspective; Differentiation Potential of Bone Marrow-Derived MSCs; Adipocytes, osteoblasts, chondrocytes and haematopoiesis-supportive stroma; Tenocytes; Cardiac and skeletal muscle cells; Hepatocytes; Neural; In vivo differentiation potential; Isolation of MSCs from Site Other Than the Bone Marrow; Multipotent Adult Progenitor Cells; MSC Cell Surface Markers; Self-Renewal of MSCs. 
505 8 |a Signalling Pathways Involved in MSC Proliferation and DifferentiationConclusion; References; Chapter 2. Mesenchymal Stem Cells: From Culture to Clinic Carl A. Gregory; Introduction; Acquisition and Expansion of MSCs; MSCs for Regenerative Medicine; Modulation of the Immune Response by MSCs; MSCs as Vectors for Gene Therapy; Concluding Remarks; References; Chapter 3. Stem Cell Bioprocessing for Clinical Applications of Regenerative Medicine Athanaslos Mantalaris, Wesley L. Randle and Julia M. Polak; Introduction; Design Principles; Cells; Materials; Bioprocess characterization. 
505 8 |a Bioprocess monitoring and controlBioreactors; Conclusions; References; Chapter 4. Defining and Overcoming the Immunological Barriers to Stem Cell Therapies Nathan J. Robertson, Herman Waldmann and Paul J. Fairchild; Introduction; The Hurdles of the Immune System; How High are the Hurdles? Immunogenicity of ES Cells and Derivatives; Expression of blood group antigens; Expression of MHC Class I and MHC Class II; The role of passenger APC; Immune privilege; Sidestepping the Hurdles; Patient-specific cell lines; ES cell banking; Genetic manipulation; Jumping the Hurdles: Immune Tolerance. 
505 8 |a ConclusionAcknowledgements; References; Chapter 5. Activation of the Immune System: A Corollary of Transplantation with ES Cell-Derived Tissues Ashleigh S. Boyd, Douglas C. Wu and Kathryn J. Wood; Introduction; How Immunogenic are Stem Cell-Derived Transplants?; The major histocompatibility complex; Minor histocompatibility antigens; Allorecognition and T cell activation; Allorecognition and T cell activation; MHC expression by stem cells; Mechanisms of Immune Attack on ES Cell-Derived Transplants; Innate immunity; Pathogen recognition in innate immune responses; Adaptive immunity. 
505 8 |a Modulation of the Immune Response: Approaches to Prevent RejectionImmunosuppression; Tolerance; Genetic engineering of stem cells; Immune subterfuge: transplantation into immune-privileged areas; ES cell nuclear transfer and parthenogenesis; Concluding Remarks; References; Chapter 6. Suppression of HLA Expression by Lentivirus-Mediated Gene Transfer of siRNA Cassettes Noriyuki Kasahara; Introduction; Immunogenicity: A Problem Even for hESC-Derived Transplants; Allograft Rejection is Mediated by Immunorecognition of MHC Antigens; HLA Down-Regulation as a Novel Immunoevasion Strategy. 
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700 1 |a Gordon, M. Y.  |q (Myrtle Y.)  |1 https://id.oclc.org/worldcat/entity/E39PCjyBgJBcQ3BpHxJfc9KpxC 
700 1 |a Dimarakis, Ioannis. 
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